Reference values for spot urinary iodine concentrations in iodine-sufficient newborns using a new pad collection method
Reference values for spot urinary iodine concentrations in iodine-sufficient newborns using a new pad collection method
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DOI：
10.1089/thy.2007.0279
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发表时间：
2008-03-01
期刊：
影响因子：
6.6
通讯作者：
Zimmermann, Michael B.
中科院分区：
文献类型：
--
作者：
Dorey, Corine M.;Zimmermann, Michael B.
背景资料：婴儿期碘缺乏会损害神经认知发育，但在这一关键时期碘摄入量的可用指标很少。在许多国家，新生儿出生后头几天在产科诊所就诊的机会很高。如果能采集现场尿标本，尿碘浓度（UIC）的参考数据将有助于评估他们的碘营养状况。本研究的目的是：1）开发和验证一个简单的垫系统收集现场尿碘样本; 2）建立一个参考范围UIC在新生儿出生后的第一周用于监测碘nutrition.Methods：一个两阶段的整群抽样获得一个有代表性的国家样本的健康，长期瑞士婴儿，0至5天（n = 634）。连续两天收集GEOMENTAL信息，促甲状腺激素全血，和现场尿样。结果：垫收集系统是公认的，并在回收率和污染测试过程中表现良好。总样本（n = 1224）的中位UIC为77（95%置信区间; 76，81）μ g/L;从第1天到第4天，中位UIC在70 - 100 μ g/L范围内逐渐增加。由于尿肌酐浓度高，可变的UI：肌酐比是没有用的standardization.Conclusions：目前的世界卫生组织中位数UIC截止值（> 100微克/升）碘充足的婴儿出生后的第一周可能太高。来自碘充足新生儿的参考数据和简单的收集系统可能有助于将UIC用作该年龄组碘状况的指标。
Background: Iodine deficiency in infancy can impair neurocognitive development, but there are few available indicators of iodine intake during this critical period. In many countries, access to newborns in maternity clinics in the first few days after birth is high. If spot urine samples could be collected, reference data for urinary iodine concentration (UIC) would be useful to evaluate their iodine status. The study objectives were 1) to develop and validate a simple pad system for collection of spot urine samples for iodine; 2) to establish a reference range for UIC in newborns in the first week after birth for use in monitoring iodine nutrition.Methods: A two-stage cluster sampling was used to obtain a representative national sample of healthy, term Swiss infants, 0 to 5 days old (n = 634). Gestational information, whole blood for thyrotropin, and spot urine samples on two consecutive days were collected.Results: The pad collection system was well-accepted and performed well during recovery and contamination testing. Median UIC in the total sample (n = 1224) was 77 (95% confidence interval; 76, 81) mu g/L; there was a gradual increase in median UIC within the range of 70 - 100 mu g/L from days 1 through 4. Because urinary creatinine concentrations were high and variable, the UI: creatinine ratio was not useful for standardization.Conclusions: The current WHO median UIC cut-off (> 100 mu g/L) for iodine sufficiency in infancy may be too high for the first week after birth. Reference data from iodine-sufficient newborns and a simple collection system may facilitate use of UIC as an indicator of iodine status in this age group.