Estradiol phase-shifts circannual rhythms of golden-mantled ground squirrels.
Estradiol phase-shifts circannual rhythms of golden-mantled ground squirrels.
复制标题
雌二醇改变了金披地松鼠的昼夜节律。
DOI：
10.1152/ajpregu.1992.262.6.r1096
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Zucker,I
中科院分区：
文献类型：
--
作者：
Lee,TM;Zucker,I
卵巢切除的金背地松鼠（Spermophilus lateralis）植入雌二醇苯甲酸（EB）填充或空胶囊。在激素治疗之前、期间和之后监测体重至少1年。EB治疗6-7个月的时间，限制在体重增加阶段，体重增加减速，并延迟达到峰值体重34天;期间的circannual节奏，连续谷重之间测量，是36天以上的松鼠与雌二醇治疗比未处理的动物。EB治疗持续2- 4个月，仅限于体重减轻期，加速体重减轻，提前57天达到谷值体重，并将年周期缩短66天。雌激素诱导的相位延迟和进展在激素治疗停止后的一年中得以保留。这些结果有利于存在的circannual相位响应曲线的激素，并提供了一个系统的circannual节奏的药理学操作。
Ovariectomized golden-mantled ground squirrels (Spermophilus lateralis) were implanted with estradiol benzoate (EB)-filled or empty capsules. Body weight was monitored for at least 1 yr before, during, and after hormone treatment. EB treatment of 6-7 mo duration, restricted to the weight-gain phase, decelerated weight gain and delayed attainment of peak weight by 34 days; the period of the circannual rhythm, measured between successive trough weights, was 36 days longer in squirrels treated with estradiol than in untreated animals. EB treatment of 2- to 4-mo duration, restricted to the weight-loss phase, accelerated weight loss, advanced attainment of trough weights by 57 days, and decreased the period of the circannual rhythm by 66 days. Estradiol-induced phase delays and advances were preserved in the year after discontinuation of hormone treatment. These results favor the existence of circannual phase-response curves to hormones and provide a system for pharmacological manipulation of circannual rhythms.