Identification of the anterior corticospinal tract in the human brain using diffusion tensor imaging
Identification of the anterior corticospinal tract in the human brain using diffusion tensor imaging
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DOI：
10.1016/j.neulet.2011.10.020
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发表时间：
2011-11-21
影响因子：
2.5
通讯作者：
Jang, Sung Ho
中科院分区：
文献类型：
--
作者：
Kwon, Hyeok Gyu;Lee, Dong Gyu;Jang, Sung Ho
皮质脊髓束（CST）通常分为交叉的外侧CST和不交叉的前CST。没有扩散张量成像研究，以确定在人类大脑中的前部CST已经进行。利用扩散张量成像，我们试图确定前CST和正常人脑前CST的特点进行了研究。我们招募了15名健康志愿者参与这项研究。采用1.5T磁共振弥散张量成像。对于整个CST，将两个感兴趣区域放置在脑桥和上髓质的CST区域上。相比之下，对于前部CST，在上颈髓的前索上给出了额外的感兴趣区域。起源于大脑皮质的前皮质脊髓束通过已知的皮质脊髓束途径下行，终止于上颈髓前索。与完整的CST相比，前部CST的纤维数量、各向异性分数和表观扩散系数均减少（P < 0.05）。前侧CST的平均纤维数占全部CST的12.4%。我们对前皮质脊髓束进行了识别，发现其与整个皮质脊髓束相比，具有方向性差、纤维少的特点。我们相信，本研究的方法和结果将有助于研究正常人脑的运动控制和脑损伤后的运动恢复机制。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
The corticospinal tract (CST) is generally classified into the crossed lateral CST and the uncrossed anterior CST. No diffusion tensor imaging study for identification of the anterior CST in the human brain has been conducted. Using diffusion tensor imaging, we attempted to identify the anterior CST and investigate the characteristics of the anterior CST in the normal human brain. We recruited 15 healthy volunteers for this study. Diffusion tensor images were scanned using 1.5T. For the whole CST, two regions of interest were placed on the CST area of the pons and upper medulla. By contrast, for the anterior CST, an additional region of interest was given on the anterior funiculus of the upper cervical cord. The anterior CSTs, which originated from the cerebral cortex descended through the known pathway of the CST, and terminated in the anterior funiculus of the upper cervical cord. Compared with whole CSTs, the anterior CSTs showed decreased fiber number, fractional anisotropy, and apparent diffusion coefficient (P < 0.05). The mean fiber number of the anterior CST was 12.4% of the whole CSTs. We identified the anterior CST and found that it has the characteristics of less directionality and fewer fibers in comparison with the whole CST. We believe that the methodology and results of this study would be helpful in research on motor control in the normal human brain and motor recovery mechanisms following brain injury. (C) 2011 Elsevier Ireland Ltd. All rights reserved.