Current concepts and controversies in chemical carcinogenesis.
Current concepts and controversies in chemical carcinogenesis.
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化学致癌的当前概念和争议。
DOI：
10.1002/jsscb.380170202
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Weinstein,IB
中科院分区：
文献类型：
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作者：
Weinstein,IB
当我被邀请在这次Keystone会议上发表主题演讲时，我感到非常荣幸，但我不确定我的责任是什么。所以我查阅了韦伯斯特的字典，上面说：“基调演讲：一个演讲（如在政治会议上），旨在向大会提出主要关注的问题，但往往集中在唤起团结和热情。”实际上，这是一个合适的作业，因为化学致癌作用的主题确实是一个令人兴奋的主题，至少有三个原因。第一，它涉及一种重大疾病，因为癌症是美国和西方世界的第二大死亡原因。第二，它探讨了当代生物学中一些最基本的问题，即与DNA结构、染色质和基因表达控制、膜结构和功能、生长控制的最基本问题以及细胞分化的特异性和稳定性有关的问题。第三，它汇集了来自流行病学、毒理学、细胞生物学和分子遗传学等不同学科的研究人员。因此，在这些天的专业化到无聊的地步，在致癌作用的调查人员可以保持一个文艺复兴时期的人！
When I was invited to present the Keynote Address at this Keystone Conference I was quite flattered, but I wasn’t certain what my responsibilities were. So I consulted Webster’s dictionary, which said “keynote address: an address (as at a political convention) intended to present the issues of primary concern to the assembly but often concentrated upon arousing unity and enthusiasm.” This is, actually, an appropriate assignment since the subject of chemical carcinogenesis is truly an exciting one for at least three reasons. One, it deals with a disease of major magnitude, since cancer is the second leading cause of death in the United States and the Western World. Two, it probes some of the most fundamental questions in contemporary biology, ie, questions related to DNA structure, chromatin and the control of gene expression, membrane structure and function, the very basic problem of growth control, and the specificity and stability of cellular differentiation. Three, it brings together investigators from such diverse disciplines as epidemiology, toxicology, cell biology, and molecular genetics. Thus, in these days of specialization to the point of boredom, the investigator in carcinogenesis can remain a renaissance person!