Suicide attempts in an adolescent female twin sample
Suicide attempts in an adolescent female twin sample
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DOI：
10.1097/00004583-200111000-00010
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发表时间：
2001-11-01
影响因子：
13.3
通讯作者：
Heath, AC
中科院分区：
文献类型：
--
作者：
Glowinski, AL;Bucholz, KK;Heath, AC
目的：检查流行病学和遗传信息丰富的青少年样本中的自杀企图。方法：从 1995 年到 2000 年，通过电话版的儿童酗酒遗传学儿童半结构化评估（其中包括详细的自杀行为部分）对 3,416 名密苏里州女性青少年双胞胎（85% 的参与率）进行了访谈。评估时的平均年龄为 15.5 岁。结果：4.2% 的受试者报告至少有一次自杀企图。首次自杀尝试均发生在 18 岁之前（平均年龄 13.6 岁）。重度抑郁症、酒精依赖、儿童期身体虐待、社交恐惧症、行为障碍和非裔美国人是与自杀未遂史最相关的因素。自杀倾向具有家族性，遗传和共同的环境影响共同导致了风险差异的 35% 至 75%。在控制其他精神危险因素后，同卵双胞胎的双胞胎/双胞胎自杀企图比值比为 5.6（95% 置信区间 [CI] 1.75-17.8），异卵双胞胎为 4.0（95% CI 1.1-14.7）。结论：在女性中，自杀倾向似乎通常首先在青春期显现出来。数据显示，青少年自杀企图具有家族性，并且可能受到遗传因素的影响，即使在控制其他精神病理学的情况下也是如此。
Objective: To examine suicide attempts in an epidemiologically and genetically informative youth sample. Method: 3,416 Missouri female adolescent twins (85% participation rate) were interviewed from 1995 to 2000 with a telephone version of the Child Semi-Structured Assessment for the Genetics of Alcoholism, which includes a detailed suicidal behavior section. Mean age was 15.5 years at assessment. Results: At least one suicide attempt was reported by 4.2% of the subjects. First suicide attempts were all made before age 18 (and at a mean age of 13.6). Major depressive disorder, alcohol dependence, childhood physical abuse, social phobia, conduct disorder, and African-American ethnicity were the factors most associated with a suicide attempt history. Suicide attempt liability was familial, with genetic and shared environmental influences together accounting for 35% to 75% of the variance in risk. The twin/cotwin suicide attempt odds ratio was 5.6 (95% confidence interval [CI] 1.75-17.8) for monozygotic twins and 4.0 (95% Cl 1.1-14.7) for dizygotic twins after controlling for other psychiatric risk factors. Conclusions: In women, the predisposition to attempt suicide seems usually to manifest itself first during adolescence. The data show that youth suicide attempts are familial and possibly influenced by genetic factors, even when controlling for other psychopathology.