Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells.
Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells.
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DOI：
10.1586/ehm.10.33
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发表时间：
2010-08
影响因子：
2.8
通讯作者：
Miao CH
中科院分区：
文献类型：
--
作者：
Miao CH
Approximately 25–30% of the hemophilia A patients develop inhibitory antibodies against Factor VIII (FVIII) following protein-replacement therapy. This problem is also thought to occur following gene-replacement therapy. Recently, many approaches have been investigated to modulate FVIII-specific immune responses in either protein-replacement or gene therapy hemophilia A mouse models. Several promising protocols have been demonstrated to successfully prevent or modulate the formation of anti-FVIII antibodies, including methods to manipulate antigen presentation, development of less immunogenic FVIII proteins, or formulations or gene therapy protocols to evade immune responses, as well as immunomodulation strategies to target either T- and/or B-cell responses. Most of these successful protocols involve the induction of activated Treg cells to create a regulatory immune environment during tolerance induction. Innovative strategies to overcome pre-existing anti-FVIII immune responses and induce long-term tolerance in primed subjects still need to be developed.
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影响因子：
2.9
作者：
DAVIE, EW;FUJIKAWA, K;KISIEL, W
通讯作者：
KISIEL, W
影响因子：
3.9
作者：
Carlborg, E;Astermark, J;Berntorp, E
通讯作者：
Berntorp, E
DOI：
10.1073/pnas.95.10.5734
发表时间：
1998-05-12
影响因子：
11.1
作者：
Evans, GL;Morgan, RA
通讯作者：
Morgan, RA
影响因子：
82.9
作者：
Brown, Brian D.;Venneri, Mary Anna;Naldini, Luigi
通讯作者：
Naldini, Luigi
DOI：
10.1111/j.1538-7836.2009.03417.x
发表时间：
2009-07
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Cao O;Loduca PA;Herzog RW
通讯作者：
Herzog RW