The cell biological application of carbon nanotube probes for atomic force microscopy: comparative studies of malaria-infected erythrocytes.
The cell biological application of carbon nanotube probes for atomic force microscopy: comparative studies of malaria-infected erythrocytes.
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原子力显微镜碳纳米管探针的细胞生物学应用：疟疾感染红细胞的比较研究。
DOI：
10.1093/oxfordjournals.jmicro.a023828
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Dvorak,JA
中科院分区：
文献类型：
--
作者：
Nagao,E;Nishijima,H;Akita,S;Nakayama,Y;Dvorak,JA
我们描述了碳纳米管（CN）探针在原子力显微镜研究中的首次细胞生物学应用。使用 TappingMode 蚀刻硅探针（TESP 探针）和 CN 探针收集恶性疟原虫感染的红细胞的形貌图像和相位图像。我们估计 CN 探针生成的地形图像的横向分辨率至少比 TESP 探针高四倍。碳纳米管探针生成的 P 相图像。红细胞表面的恶性疟原虫诱导的旋钮也显示出比相同区域的类似 TESP 探针生成的相位图像明显更高的横向分辨率。我们得出的结论是，CN 探针对于细胞生物原子力显微镜研究很有用，并且应该在这个不断发展的学科的未来中发挥越来越重要的作用。
We describe the first cell biological application of carbon nanotube (CN) probes for atomic force microscopy studies. Topographic and phase images were collected fromPlasmodium falciparummalaria-infected erythrocytes using both TappingMode Etched Silicon Probes (TESP probe) and CN probes. We estimate that the lateral resolution of a CN probe-generated topographic image is at least four-fold higher than that of the TESP probe. Carbon nanotube probe-generated phase images ofP. falciparum-induced knobs on the surface of erythrocytes also show a markedly higher lateral resolution than comparable TESP probe-generate phase images of the same area. We conclude that CN probes are useful for cell biological atomic force microscopy studies and should play an increasingly important role in the future of this evolving discipline.