Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster.
Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster.
复制标题
果蝇中 X 连锁重复之间相对于多态性的氨基酸取代过多。
DOI：
10.1093/molbev/msi015
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Long,Manyuan
中科院分区：
文献类型：
--
作者：
Thornton,Kevin;Long,Manyuan
We have obtained sequence polymorphism data from 13 genes belonging to 5 gene families inDrosophila melanogasterwhere theKa/Ksbetween copies is greater than 1. Twelve of these 13 loci are X-linked. In general, there is evidence of purifying selection in all families, as inferred both from levels of silent and replacement variation and insertion/deletion variation, suggesting that the loci are likely functional. Shared polymorphisms indicative of gene conversion between paralogs are rare among the X-linked families, in contrast to available data from autosomal duplicates. McDonald-Kreitman tests between duplicates reveal an excess of amino-acid fixations between copies in the X-linked families, suggesting that the divergence between these loci was driven by positive selection. In contrast, available data from autosomal duplicates show a deficit of fixations, consistent with gene conversion being a strong homogenizing force.
