Assessment of cortical degeneration in patients with Parkinson's disease by voxel-based morphometry, cortical folding, and cortical thickness
Assessment of cortical degeneration in patients with Parkinson's disease by voxel-based morphometry, cortical folding, and cortical thickness
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DOI：
10.1002/hbm.21378
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发表时间：
2012-11-01
影响因子：
4.8
通讯作者：
Tolosa, Eduardo
中科院分区：
文献类型：
--
作者：
Pereira, Joana Braga;Ibarretxe-Bilbao, Naroa;Tolosa, Eduardo
非侵入性脑成像方法提供了有用的信息，大脑退化和退行性过程。在这里，我们评估了20名非痴呆帕金森病（PD）患者和20名健康对照者的皮质变性，使用三种定量神经解剖学方法：基于体素的形态测量（VBM），皮质折叠（BrainVisa）和皮质厚度（FreeSurfer）。我们研究了全球和区域的灰质（GM）的体积，脑沟指数和厚度的措施，从以前的方法，以及它们与认知能力，年龄，运动症状的严重程度和疾病阶段之间的关系。VBM分析显示，与对照组相比，患者左侧颞回的GM体积减少。皮质折叠测量显示患者的左额叶和右侧副沟显著减少。最后，皮质厚度分析显示，广泛的皮质变薄，在右侧枕叶，顶叶和左颞叶，额叶，和运动前区。我们发现，在患者中，所有的全球解剖测量与年龄相关，而GM体积和皮质厚度与疾病分期显着相关。在对照组中，发现全球GM体积和皮质折叠与年龄之间存在显着关联。总体而言，这些结果表明，三种不同的方法提供了互补的和相关的信息发生在PD的神经退行性变化，然而，基于表面的措施皮质折叠，特别是皮质厚度似乎比VBM更敏感，以确定区域GM的变化与PD。^Brain Mapp，2012. (c)2011 Wiley Periodicals，Inc.
Noninvasive brain imaging methods provide useful information on cerebral involution and degenerative processes. Here we assessed cortical degeneration in 20 nondemented patients with Parkinson's disease (PD) and 20 healthy controls using three quantitative neuroanatomical approaches: voxel-based morphometry (VBM), cortical folding (BrainVisa), and cortical thickness (FreeSurfer). We examined the relationship between global and regional gray matter (GM) volumes, sulcal indices, and thickness measures derived from the previous methods as well as their association with cognitive performance, age, severity of motor symptoms, and disease stage. VBM analyses showed GM volume reductions in the left temporal gyrus in patients compared with controls. Cortical folding measures revealed significant decreases in the left frontal and right collateral sulci in patients. Finally, analysis of cortical thickness showed widespread cortical thinning in right lateral occipital, parietal and left temporal, frontal, and premotor regions. We found that, in patients, all global anatomical measures correlated with age, while GM volume and cortical thickness significantly correlated with disease stage. In controls, a significant association was found between global GM volume and cortical folding with age. Overall these results suggest that the three different methods provide complementary and related information on neurodegenerative changes occurring in PD, however, surface-based measures of cortical folding and especially cortical thickness seem to be more sensitive than VBM to identify regional GM changes associated to PD. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.