Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.
Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.
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DOI：
10.1097/phm.0b013e31817c1945
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发表时间：
2008-09
影响因子：
3
通讯作者：
Yejia Zhang;H. An;C. Tannoury;E. Thonar;M. Freedman;D. Anderson
中科院分区：
文献类型：
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作者：
Yejia Zhang;H. An;C. Tannoury;E. Thonar;M. Freedman;D. Anderson
脊柱护理是一个快速增长的部门门诊实践的物理医生。目前对严重症状性椎间盘退变的非手术治疗方式和手术选择的临床结果有限且不一致。因此，新方法的发展，如生物治疗，提供了停止甚至逆转椎间盘退变和恢复生理椎间盘功能的潜力，是非常有吸引力的。在本文中，我们首先回顾了椎间盘退变期间发生的结构变化及其与椎间盘源性背痛的关系。随后，我们回顾了目前正在进行临床试验和实验室研究的治疗方法。专门从事脊柱护理的理疗师具备管理椎间盘内注射和监督手术后全面康复计划所需的技能。最终，这里讨论的任何生物治疗的临床应用都需要内科医生（如物理医生和外科医生）和研究人员（如化学和生物医学工程师、生物学家和化学家）的共同努力。
Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of novel approaches, such as biological treatments that offer the potential to halt or even reverse disc degeneration and restore physiologic disc function, are very attractive. In this article, we first review the structural changes that occur during intervertebral disc degeneration and their relationship with discogenic back pain. Subsequently, we review the treatment approaches currently under clinical trial and laboratory investigation. Physiatrists specializing in spine care have the skill set required for administering intradiscal injections and supervising a comprehensive rehabilitation program after the procedures. Ultimately, the clinical use of any biological treatment discussed herein would require the collective efforts of physicians (such as physiatrists and surgeons) and researchers (such as chemical and biomedical engineers, biologists, and chemists).