TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA
TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA
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DOI：
10.1093/bioinformatics/bti211
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发表时间：
2005-04-15
期刊：
影响因子：
5.8
通讯作者：
Wang, SQ
中科院分区：
文献类型：
--
作者：
Bo, XC;Wang, SQ
TargetFinder 是一个 PC/Windows 程序，用于基于 mRNA 可及位点标记 (MAST) 和目标 mRNA 二级结构进行交互式有效反义寡核苷酸 (AO) 选择。为了使 MAST 结果直观，对比对结果和标签频率曲线进行了说明。作为理论参考，还展示了目标 mRNA 的二级结构和单链概率图谱。所有这些序列和概况都以对齐模式显示，这有助于识别目标 mRNA 中的可访问位点。图形化、用户友好的界面使 TargetFinder 成为 AO 目标站点选择的有用工具。
TargetFinder is a PC/Windows program for interactive effective antisense oligonucleotide (AO) selection based on mRNA accessible site tagging (MAST) and secondary structures of target mRNA. To make MAST result intuitive, both the alignment result and tag frequency profile is illustrated. As theoretical reference, secondary structure and single strand probability profile of target mRNA is also represented. All of these sequences and profiles are displayed in aligned mode, which facilitates identification of the accessible sites in target mRNA. Graphical, user-friendly interface makes TargetFinder a useful tool in AO target site selection.