RAISED HISTAMINE CONCENTRATIONS IN CHRONIC CHOLESTATIC LIVER-DISEASE
RAISED HISTAMINE CONCENTRATIONS IN CHRONIC CHOLESTATIC LIVER-DISEASE
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DOI：
10.1136/gut.31.1.96
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发表时间：
1990-01-01
期刊：
影响因子：
24.5
通讯作者：
MADDREY, WC
中科院分区：
文献类型：
--
作者：
GITTLEN, SD;SCHULMAN, ES;MADDREY, WC
瘙痒是慢性胆汁淤积性肝病的常见症状。迄今为止，尚未确定单一的致病机制。我们用高灵敏度的放射酶分析法检测了42例慢性胆汁淤积性肝病患者和正常对照者的静脉血浆中已知促胆汁生成剂组胺的浓度。平均血浆组胺水平在慢性胆汁淤积性肝病患者中显著更高（275（117）pg/ml; (SD)与对照组（140（72）pg/ml，n = 20）相比（p < 0.0001）。在原发性胆汁性肝硬化和硬化性胆管炎这两个慢性胆汁淤积性肝病亚组中，组胺浓度没有显著差异。慢性胆汁淤积性肝病患者的组胺浓度（319（132）pg/ml）显著高于非胆汁淤积性肝病患者（227（75）pg/ml）（p < 0.01）。患者组和对照组的组胺酶活性相当。慢性胆汁淤积性肝病中组胺浓度升高的发现提示体内肥大细胞活化及其介质在这些疾病的特征性肠炎中的潜在作用。
Pruritus is a frequent symptom in chronic cholestatic liver disease. To date, no single causative mechanism has been identified. We examined venous plasma concentrations of the known pruritogen, histamine, using a highly sensitive radioenzymatic assay in 42 patients with chronic cholestatic liver disease, and in normal controls. The mean plasma histamine level was significantly greater in chronic cholestatic liver disease patients (275 (117) pg/ml; .times. (SD) than in controls (140 (72) pg/ml, n = 20) (p < 0.0001). No significant differences were found between histamine concentrations in the two chronic cholestatic liver disease subgroups: primary biliary cirrhosis and sclerosing cholangitis. Histamine concentrations were significantly greater (p < 0.01) in the pruritic (319 (132) pg/ml) as compared with the non-pruritic (227 (75) pg/ml) chronic cholestatic liver disease patients. The histaminase activity was equivalent in patients and controls. The finding of raised histamine concentrations in chronic cholestatic liver disease suggests in vivo mast cell activation and a potential role for its mediators in the pruritis characteristic of these disorders.