Foveal Avascular Zone Distortion in Epiretinal Membrane by Optical Coherence Tomography Angiography.
Foveal Avascular Zone Distortion in Epiretinal Membrane by Optical Coherence Tomography Angiography.
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DOI：
10.3928/23258160-20190503-06
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发表时间：
2019-05-01
期刊：
影响因子：
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通讯作者：
Freeman, William R
中科院分区：
文献类型：
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作者：
Muftuoglu, Ilkay Kilic;Amador, Manuel;Freeman, William R
背景与目的：应用光学相干断层血管成像(OCTA)技术显示视网膜前膜(ERM)患者黄斑中心凹无血管区(FAZ)的形态变化，探讨FAZ变形与ERM特征的相关性。方法：测量52例ERM患者的FAZ偏心率指数(FAZ最长径/FAZ最短径)，并与27例健康者进行比较。结果：52眼ERM患者中，31眼(59.61%)出现黄斑中心凹改变，包括FAZ完全或部分血管化(13.46%)或部分改变(30.76%)，有血管穿过中心凹(9.61%)，FAZ水平或垂直延长(5.76%)。ERM组平均FAZ偏心指数为0.84±0.46(0.0~1.86)，对照组为0.98±0.07(0.96~1.02)(P=0.02)。FAZ偏心指数与中心黄斑厚度呈显著负相关(P=0.04)。结论：ERM眼中央黄斑中心凹增厚可导致黄斑中心凹重塑，OCTA可直观显示建筑FAZ的变化。眼科激光成像视网膜。2019年；50：295-301。]
BACKGROUND AND OBJECTIVE: To show the morphologic changes on the foveal avascular zone (FAZ) in patients with epiretinal membrane (ERM) using optical coherence tomography angiography (OCTA) and to demonstrate the correlation between distortion of FAZ and features of the ERM.PATIENTS AND METHODS: FAZ eccentricity index (longest diameter of FAZ/shortest diameter of FAZ) was measured in 52 patients with ERM and compared with 27 healthy subjects' values. The density of the ERM was quantified using a grading scale (0-3) on multicolor scanning laser images, and spectral-domain OCT characteristics of the eyes were assessed.RESULTS: Of the 52 eyes with ERM, 31 eyes (59.61%) showed some foveal remodeling, including full (13.46%) or partial (30.76%) apparent vascularization of FAZ, presence of a vessel crossing the fovea (9.61%), and horizontal or vertical elongation of FAZ (5.76%). The mean FAZ eccentricity index was 0.84 ± 0.46 (range: 0.0-1.86) in eyes with ERM and 0.98 ± 0.07 (range: 0.96-1.02) in the control subjects, respectively (P = .02). There was a negative significant correlation between FAZ eccentricity index and central macular thickness (P = .04).CONCLUSIONS: Thickening of the central fovea leads to foveal remodeling in ERM eyes, and OCTA enables the visualization of architectural FAZ changes. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:295-301.].