Epstein-barr virus in gastric carcinoma.
Epstein-barr virus in gastric carcinoma.
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DOI：
10.3390/cancers6042259
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发表时间：
2014-11-07
期刊：
影响因子：
5.2
通讯作者：
Sakaida I
中科院分区：
文献类型：
--
作者：
Nishikawa J;Yoshiyama H;Iizasa H;Kanehiro Y;Nakamura M;Nishimura J;Saito M;Okamoto T;Sakai K;Suehiro Y;Yamasaki T;Oga A;Yanai H;Sakaida I
EB病毒（Epstein-Barr virus，EBV）在世界范围内约10%的胃癌病例中检出。在EBV相关的胃癌中，所有肿瘤细胞都具有克隆性EBV基因组。EBV相关性胃癌具有独特的临床病理特征，主要发生在男性和中老年个体中，并呈现出普遍弥漫的组织学类型。大多数EB病毒相关胃癌的组织学表现为淋巴细胞浸润。宿主的免疫反应性可能代表EBV阳性病例的相对较好的预后。这一事实突出了EBV在EBV相关胃癌的发展中的重要作用。明确证实EBV可直接感染人胃上皮细胞。通过使用重组EBV实现感染。在细胞中观察到EBV感染促进生长。相当多的数据表明，EBV可能直接导致EBV相关的GC的发展。这种肿瘤促进作用似乎涉及多种机制，因为EBV影响几种通常促进细胞凋亡和调节细胞增殖的宿主蛋白和途径。
The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma, all tumor cells harbor the clonal EBV genome. Gastric carcinoma associated with EBV has distinct clinicopathological features, occurs predominately in men and in younger-aged individuals, and presents a generally diffuse histological type. Most cases of EBV-associated gastric carcinoma exhibit a histology rich in lymphocyte infiltration. The immunological reactiveness in the host may represent a relatively preferable prognosis in EBV-positive cases. This fact highlights the important role of EBV in the development of EBV-associated gastric carcinoma. We have clearly proved direct infection of human gastric epithelialcells by EBV. The infection was achieved by using a recombinant EBV. Promotion of growth by EBV infection was observed in the cells. Considerable data suggest that EBV may directly contribute to the development of EBV-associated GC. This tumor-promoting effect seems to involve multiple mechanisms, because EBV affects several host proteins and pathways that normally promote apoptosis and regulate cell proliferation.
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