Rethinking paradigms for studying mechanisms of action of plant bioactives.
Rethinking paradigms for studying mechanisms of action of plant bioactives.
复制标题
DOI：
10.1111/nbu.12178
复制
发表时间：
2015-12
影响因子：
3.3
通讯作者：
Kay CD
中科院分区：
文献类型：
--
作者：
Kay CD
我们饮食中的许多食物，如浆果、茶、巧克力和葡萄酒都含有类黄酮，这是植物的天然成分。大量证据支持类黄酮在预防心脏代谢疾病和紊乱方面的作用。尽管在过去的20年里，类黄酮研究几乎呈指数级增长，但在了解这些饮食成分是如何发挥作用方面取得的进展有限。最初的研究集中在它们的抗氧化活性上，而没有考虑它们的新陈代谢，现在看来这一点很广泛。这为理解黄酮类代谢物的生物活性提供了新的研究动力。在这里，我们概述了最近的研究，这些研究表明新陈代谢、肠道菌群、免疫系统和我们身体的各种组织之间存在着高度复杂的相互作用。
Many foods in our diets such as berries, tea, chocolate and wine contain flavonoids, which are natural components of plants. A substantial body of evidence supports the role of flavonoids in providing protection against cardio-metabolic diseases and disorders. Despite the nearly exponential growth in flavonoid research in the past 20 years, limited progress has been made in understanding how these dietary components work. Research initially focused on their antioxidant activity without taking into account their metabolism, which now appears extensive. This has provided a new research impetus to understand the biological activity of the flavonoid metabolites. Here, we outline recent research, which suggests a highly complex interplay between metabolism, intestinal microflora, the immune system and various tissues of our body.