Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
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DOI：
10.1126/science.286.5449.2511
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发表时间：
1999-12-24
期刊：
影响因子：
56.9
通讯作者：
McDonald, DM
中科院分区：
文献类型：
--
作者：
Thurston, G;Suri, C;McDonald, DM
血管生成素-1（Ang 1）和血管内皮生长因子（VEGF）是内皮细胞特异性生长因子。直接比较在皮肤中过度表达这些因子的转基因小鼠，发现VEGF诱导的血管是渗漏的，而Ang 1诱导的血管是非渗漏的。此外，血管生成素1过表达小鼠的血管对炎性因子引起的渗漏有抵抗力。Ang 1和VEGF的共表达对血管生成有相加作用，但导致Ang 1典型的抗渗漏血管。因此，Ang 1可用于减少由慢性炎症或VEGF升高引起的微血管渗漏，并与VEGF联合用于促进无渗漏血管的生长。
Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were Leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to Leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in Leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular Leakage in diseases in which the Leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.