Audiogenic reflex seizures in cats.
Audiogenic reflex seizures in cats.
复制标题
DOI：
10.1177/1098612x15582080
复制
发表时间：
2016-04
影响因子：
1.7
通讯作者：
Garosi L
中科院分区：
文献类型：
--
作者：
Lowrie M;Bessant C;Harvey RJ;Sparkes A;Garosi L
本研究旨在表征猫听源反射性癫痫发作 (FARS)。我们开发了一份在线调查问卷，以收集患有 FARS 的猫的主人的信息。这是与初级兽医的医疗记录进行了核对。其中包括九十六只猫。肌阵挛发作是该综合征的主要症状之一 (90/96)，在该人群中经常发生在全身强直阵挛发作 (GTCS) 之前。其他特征包括迟发（中位 15 年）和失神癫痫发作（6/96），大多数癫痫发作是由高频声音引发的，偶尔有自发性癫痫发作（高达 20%）。一半人口（48/96）有听力障碍或失聪。三分之一的猫（35/96）患有并发疾病，很可能反映了年龄分布。伯曼人的代表性很强（30/96）。左乙拉西坦可以很好地控制癫痫发作。大多数人（68/96）的癫痫病程是非进行性的，有些人（23/96）随着时间的推移，癫痫病程有所改善。只有 33/96 和 11/90 的主人分别认为 GTCS 和肌阵挛癫痫发作影响了猫的生活质量 (QoL)。尽管如此，许多主人（50/96）报告说，他们的猫的健康状况缓慢下降，反应迟钝（43/50），不跳跃（41/50），骨盆四肢变得不协调或虚弱（24/50），并且体重急剧下降（39/50）。这些症状仅出现在癫痫发作超过 2 年的猫身上，42/50 的主人表示这些症状影响了猫的生活质量。在收集猫听源性癫痫发作的数据时，我们发现了一种名为 FARS 的新癫痫综合征，其发病年龄为老年。需要进一步研究来调查这种情况的潜在遗传倾向。
This study aimed to characterise feline audiogenic reflex seizures (FARS). An online questionnaire was developed to capture information from owners with cats suffering from FARS. This was collated with the medical records from the primary veterinarian. Ninety-six cats were included. Myoclonic seizures were one of the cardinal signs of this syndrome (90/96), frequently occurring prior to generalised tonic–clonic seizures (GTCSs) in this population. Other features include a late onset (median 15 years) and absence seizures (6/96), with most seizures triggered by high-frequency sounds amid occasional spontaneous seizures (up to 20%). Half the population (48/96) had hearing impairment or were deaf. One-third of cats (35/96) had concurrent diseases, most likely reflecting the age distribution. Birmans were strongly represented (30/96). Levetiracetam gave good seizure control. The course of the epilepsy was non-progressive in the majority (68/96), with an improvement over time in some (23/96). Only 33/96 and 11/90 owners, respectively, felt the GTCSs and myoclonic seizures affected their cat’s quality of life (QoL). Despite this, many owners (50/96) reported a slow decline in their cat’s health, becoming less responsive (43/50), not jumping (41/50), becoming uncoordinated or weak in the pelvic limbs (24/50) and exhibiting dramatic weight loss (39/50). These signs were exclusively reported in cats experiencing seizures for >2 years, with 42/50 owners stating these signs affected their cat’s QoL. In gathering data on audiogenic seizures in cats, we have identified a new epilepsy syndrome named FARS with a geriatric onset. Further studies are warranted to investigate potential genetic predispositions to this condition.