Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study.
Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study.
复制标题
黑人女性绝经状态下血压变异性与内皮素 1 的关联：杰克逊心脏研究的结果。
DOI：
10.1038/s41371-023-00824-y
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发表时间：
2023
影响因子：
2.7
通讯作者：
Cohen,JordanaB
中科院分区：
文献类型：
--
作者：
Rethy,Leah;Polsinelli,VincenzoB;Muntner,Paul;Bello,NatalieA;Cohen,JordanaB
致编辑与绝经前女性相比，绝经后女性患高血压的风险更高，这可能与循环雌激素水平较低的情况下内皮功能障碍增加有关。使用杰克逊心脏研究 (JHS) 中 660 名女性的数据，与绝经前女性相比，绝经后女性的白天、夜间和 24 小时收缩压变异性 (BPV) 较高，并且夜间收缩压变异性较高与绝经后女性较高的内皮素-1（内皮功能障碍的标志物）相关（ß = 0.27 [0.05， 0.50]，p= 0.019），即使在调整了包括年龄在内的可能的混杂因素之后也是如此。这些发现强调了绝经状态与血压变异性的相关性，以及血压变异性在绝经后女性高内皮素-1 发展中的潜在作用。
To the EditorPostmenopausal women have a higher risk of hypertension compared with premenopausal women possibly related to increased endothelial dysfunction in the setting of lower levels of circulating estrogen. Using data from 660 women in the Jackson Heart Study (JHS), postmenopausal women had higher daytime, nighttime and 24 h systolic blood pressure variability (BPV) compared with premenopausal women, and higher nighttime systolic BPV was associated with higher endothlin-1 (a marker of endothelial dysfunction) in postmenopausal women (ß = 0.27 [0.05, 0.50],p= 0.019), even after adjustment for possible confounders including age. These findings highlight the relevance of menopause status to blood pressure variability and the potential role of blood pressure variability in the development of high endothelin-1 in postmenopausal women.