Links Between Physical Frailty and Regional Gray Matter Volumes in Older Adults: A Voxel-Based Morphometry Study
Links Between Physical Frailty and Regional Gray Matter Volumes in Older Adults: A Voxel-Based Morphometry Study
复制标题
DOI：
10.1016/j.jamda.2019.09.001
复制
发表时间：
2019-12-01
影响因子：
7.6
通讯作者：
Arai, Hidenori
中科院分区：
文献类型：
--
作者：
Nishita, Yukiko;Nakamura, Akinori;Arai, Hidenori
目的：身体虚弱和区域灰质体积在大脑中的关系进行了调查，在社区居住的老年人Japanese.Methods：参与者（N = 835;年龄范围65-89岁）是社区居住的老年人在大武市和东浦镇在爱知县，日本。身体虚弱是由心血管健康研究的修订标准确定的，其中包括体重减轻，缓慢，虚弱，疲惫和低体力活动。区域灰质体积进行了评估，从三维T1加权磁共振图像的统计参数映射。身体虚弱和区域灰质体积之间的关系进行了分析，协方差设计使用统计参数映射调整年龄，性别和教育level.Results：基于体素的分析表明，身体虚弱本身是没有显着相关的任何大脑区域。然而，虚弱与海马、杏仁核和梭状回的灰质体积减少有关，而迟钝与海马、杏仁核、梭状回、内侧前额叶和眶额皮质、额下回、初级体感皮质、颞叶、上级颞沟和小脑的灰质体积减少有关。身体虚弱的其他组成部分与任何regions.Conclusions和影响的灰质体积没有关联：身体虚弱的弱点和缓慢的组成部分与减少灰质体积在大脑区域不仅与身体的流动性，但也认知功能和社会进程。本研究从与脆弱相关的大脑结构的角度，探讨了身体、认知和社会脆弱进展的潜在机制。(C)2019作者（S）爱思唯尔公司出版代表AMDA -急性后和长期护理医学协会。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Objectives: The relationship between physical frailty and regional gray matter volume in the brain was investigated among community-dwelling older Japanese people.Methods: Participants (N = 835; age range 65-89 years) were community-dwelling older adults in Obu City and Higashiura Town in Aichi Prefecture, Japan. Physical frailty was determined by the modified criteria of the Cardiovascular Health Study, which included weight loss, slowness, weakness, exhaustion, and low physical activity. Regional gray matter volumes were evaluated from 3-dimensional T1-weighted magnetic resonance images by statistical parametric mapping. The relationship between physical frailty and regional gray matter volume was analyzed with an analysis of covariance design using statistical parametric mapping adjusting for age, sex, and education level.Results: The voxel-based analyses showed that physical frailty per se was not significantly associated with any brain region. However, weakness was associated with reduced gray matter volumes in the hippocampus, amygdala, and fusiform gyrus, and slowness was associated with reduced gray matter volumes in the hippocampus, amygdala, fusiform gyrus, medial prefrontal and orbitofrontal cortex, inferior frontal gyrus, primary somatosensory cortex, insula, superior temporal sulcus, and cerebellum. Other components of physical frailty were not associated with the gray matter volumes in any regions.Conclusions and implications: The weakness and slowness components of physical frailty were linked to reduced gray matter volume in brain regions associated with not only physical mobility but also cognitive functions and social processes. This study addressed the underlying mechanisms in the progression of physical, cognitive, and social frailty, from the perspective of brain structures that are associated with frailty. (C) 2019 The Author(s). Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).