Pentosidine and Nε-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia
Pentosidine and Nε-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia
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DOI：
10.1016/s0197-4580(02)00086-6
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发表时间：
2003-03-01
影响因子：
4.2
通讯作者：
Sauer, H
中科院分区：
文献类型：
--
作者：
Bär, KJ;Franke, S;Sauer, H
越来越多的证据表明氧化应激和晚期糖基化终产物（AGE）的形成在阿尔茨海默病的发病和进展中相互作用。我们研究了15名可能患有阿尔茨海默病（AD）的患者，20名血管性痴呆（VD）患者和31名对照组（14名年龄匹配，17名年轻患者）的血清和脑脊液（CSF）中戊糖苷和N-羧甲基赖氨酸（CML）的水平。按年龄分为两个亚组时，对照组CSF中AGE蛋白浓度无差异。我们发现，与对照组相比，AD患者CSF中CML的水平显著升高，血管性痴呆患者CSF中戊糖苷的水平显著升高。血清中戊糖苷和CML的浓度显然与CSF值没有直接关系，表明血清样本中脑外因素的影响。它的结论是，AGE蛋白质的差异影响这些类型的痴呆症，这取决于特定的神经病理学。此外，体内AGE产物的测量应依赖于CSF而不是血液样本。(C)2002年爱思唯尔科技有限公司All rights reserved.
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N-epsilon-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of 15 patients with probable Alzheimer's disease (AD), 20 patients with vascular dementia (VD), and 31 control subjects (14 matched for age, and 17 younger patients). AGE protein concentrations in CSF did not differ within controls when divided into two subgroups by age. We found significantly elevated levels of CML in CSF of AD patients and of pentosidine in CSF of patients suffering from vascular dementia when compared to controls. The concentrations of pentosidine and CML in serum apparently did not relate directly to CSF values, suggesting influence of extra-cerebral factors in serum samples. It is concluded that AGE proteins are differentially affected in these types of dementia, depending on the specific neuropathology. Furthermore, measurements of AGE products in vivo should rely on CSF rather than blood samples. (C) 2002 Elsevier Science Inc. All rights reserved.