Disturbed functional connectivity in brain tumour patients: Evaluation by graph analysis of synchronization matrices
Disturbed functional connectivity in brain tumour patients: Evaluation by graph analysis of synchronization matrices
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DOI：
10.1016/j.clinph.2006.05.018
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发表时间：
2006-09-01
影响因子：
4.7
通讯作者：
Stam, Cornelis J.
中科院分区：
文献类型：
--
作者：
Bartolomei, Fabrice;Bosma, Ingeborg;Stam, Cornelis J.
目的：脑功能是基于脑内多个不同专门区域之间的功能相互作用。功能相互作用需要解剖学上的联系以及大脑振荡的同步。目前的工作旨在评估脑肿瘤的影响，在休息时测量的脑功能连接的空间模式MEG.Methods：我们分析了统计依赖性（通过计算的同步可能性（SL，广义同步的措施））之间的MEG信号在休息时，在17例脑肿瘤和15名健康对照。根据一种方法，从图论中得出，我们还分析了网络的结构特性，通过计算两个参数从SL矩阵，集群系数C和特征路径长度L.结果：同步水平的改变被发现在患者中，并没有焦点，但涉及内半球连接。考虑到频率子带的影响是不同的，主要是在减少高频段的长距离连接和增加慢频段的本地连接。此外，图形分析揭示了正常的“小世界”网络架构的变化，除了在同步水平的变化与一些差异，根据所研究的频率sub-bands.Conclusions：脑肿瘤改变的功能连接和“网络”架构的大脑。这些改变不是焦点，并且考虑到频率子带，影响是不同的。意义：这些神经生理学变化可能有助于在脑肿瘤患者中观察到的认知改变。(c)2006年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Cerebral functions are based on the functional interactions between multiple distinct specialized regions of the brain. Functional interactions require anatomical connections as well as the synchronization of brain oscillations. The present work aims at evaluating the impact of brain tumours on spatial patterns of functional connectivity of the brain measured at rest by MEG.Methods: We analyzed the statistical dependency (by computing the synchronization likelihood (SL, a measure of generalized synchronization)) between MEG signals at rest, in 17 patients with a brain tumour and in 15 healthy controls. Following an approach that derives from graph theory, we also analyzed the architectural properties of the networks by computing two parameters from the SL matrix, the cluster coefficient C and the characteristic path length L.Results: Alterations in synchronization levels were found in the patients and were not focal but involved intra-hemispheric connectivity. Effects were different considering the frequencies sub-bands, predominating in a decrease in high frequencies bands for long-distance connections and an increase in slower bands for local connectivity. In addition, graph analysis reveals changes in the normal "small-world" network architecture in addition to changes in synchronization levels with some differences according to the studied frequency sub-bands.Conclusions: Brain tumours alter the functional connectivity and the "network" architecture of the brain. These alterations are not focal and effects are different considering the frequencies sub-bands. Significance: These neurophysiological changes may contribute to the cognitive alterations observed in patients with brain tumours. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.