HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy.
HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy.
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艾滋病脑病患者大脑中的 HTLV-III/LAV 样逆转录病毒颗粒。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
R. Price
中科院分区：
文献类型：
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作者：
L. Epstein;L. Sharer;E. Cho;Marcus Myenhofer;B. Navia;R. Price
据推测，被认为是艾滋病病原体的逆转录病毒HTLV-III/LAV也可感染中枢神经系统，直接导致艾滋病脑病。对3例艾滋病合并进行性脑病患者的脑切片进行了电子显微镜研究，发现其结构在形态上与HTLV-III/LAV逆转录病毒颗粒一致。这些颗粒主要位于多核巨细胞内，但也存在于星形胶质细胞中。细胞外间隙内也可见大量颗粒。
It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.