Voltammetric enantiomeric differentiation of tryptophan by using multiwalled carbon nanotubes functionalized with ferrocene and β-cyclodextrin
Voltammetric enantiomeric differentiation of tryptophan by using multiwalled carbon nanotubes functionalized with ferrocene and β-cyclodextrin
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DOI：
10.1016/j.electacta.2018.12.041
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发表时间：
2019-02
影响因子：
6.6
通讯作者：
Xiaohui Niu;Yang Xing;Z. Mo;R. Guo;Nijuan Liu;Zhao Pan;Zhenyu Liu;Meixuan Ouyang
中科院分区：
文献类型：
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作者：
Xiaohui Niu;Yang Xing;Z. Mo;R. Guo;Nijuan Liu;Zhao Pan;Zhenyu Liu;Meixuan Ouyang
描述了两种类型的二茂铁官能化多壁碳纳米管（MWCNT）。第一种是通过 π-π 堆积将二茂铁 (Fc) 吸附在 MWCNT 上获得的，称为 Fc/MWCNT。第二种是通过二茂铁甲酸和胺化 MWCNT 之间的缀合反应制备的，产生共价修饰的 MWCNT，称为 MWCNT-Fc。 MWCNT/Fc 比 MWCNT-Fc 具有更好的导电性。但电化学识别结果清楚地表明，MWCNTs-Fc/β-CD/GCE 对色氨酸对映体表现出比 β-CD/Fc/MWCNTs/GCE 更好的手性识别能力。结合β-环糊精（β-CD）和MWCNTs-Fc的优点，获得了1-色氨酸电化学传感器。通过SEM、TEM、TGA、拉曼光谱和XPS对其进行表征，表明Fc/MWCNTs和MWCNTs-Fc已成功合成。通过微分脉冲伏安法完成对映选择性识别。色氨酸对映体可以通过对映选择性系数 (ID-Trp/IL-Trp) 5.78 来区分。此外，还提出了β-CD识别色氨酸对映体的手性识别机制。
Two types of ferrocene-functionalized multiwalled carbon nanotubes (MWCNTs) are described. The first was obtained by adsorption of ferrocene (Fc) on MWCNTs via π-π stacking and is referred to as Fc/MWCNTs. The second was prepared via a conjugation reaction between ferrocenecarboxylic acid and aminated MWCNTs to result on covalently modified MWCNTs referred to as MWCNT-Fc. MWCNT/Fc has a better conductivity than MWCNT-Fc. But electrochemical recognition results clearly showed the MWCNTs-Fc/β-CD/GCE can exhibit better chiral recognition ability to tryptophan enantiomers than β-CD/Fc/MWCNTs/GCE. By combining the merits of β-cyclodextrin (β-CD) and MWCNTs-Fc, an electrochemical sensor forl-tryptophan was obtained. Its characterizations by SEM, TEM, TGA, Raman spectroscopy and XPS showed that the Fc/MWCNTs and MWCNTs-Fc have successfully been synthesized. Enantioselective recognition was accomplished by differential pulse voltammetry. Tryptophan enantiomers can be differentiated with an enantioselectivity coefficient (ID-Trp/IL-Trp) of 5.78. Moreover, the chiral recognition mechanism of β-CD recognition tryptophan enantiomers was proposed.