The alpha-1-adrenergic neuronal system is involved in the pulsatile release of luteinizing hormone-releasing hormone in the ovariectomized female rhesus monkey.
The alpha-1-adrenergic neuronal system is involved in the pulsatile release of luteinizing hormone-releasing hormone in the ovariectomized female rhesus monkey.
复制标题
α-1-肾上腺素能神经元系统参与切除卵巢的雌性恒河猴中黄体生成素释放激素的脉冲式释放。
DOI：
10.1159/000125744
复制
发表时间：
1991
影响因子：
4.1
通讯作者：
Terasawa,E
中科院分区：
文献类型：
--
作者：
Gearing,M;Terasawa,E
据推测，儿茶酚胺是控制LHRH释放不可或缺的。在本研究中，肾上腺素能和多巴胺能受体的作用，在控制脉冲LHRH释放的检查。采用推-拉灌流法，在去卵巢雌性恒河猴体内观察了哌唑嗪（α i-拮抗剂）、萝芙木碱（α2-拮抗剂）、普萘洛尔（β-拮抗剂）、氟哌啶醇（多巴胺拮抗剂）、SCH 23390（D1-拮抗剂）和LY 163502（D2-激动剂）对柄-正中隆起LHRH释放的影响。哌唑嗪引起LHRH释放的显着抑制。这主要是由于LHRH脉冲幅度的显著抑制，而不是脉冲频率，即脉冲间期不受哌唑嗪给药的影响。与哌唑嗪相反，没有其他肾上腺素能或多巴胺能药物对LHRH释放有显着影响。结果表明：（1）去甲肾上腺素（NE）和/或肾上腺素对LHRH脉冲性释放的刺激作用是由α_1肾上腺素能受体介导的，而不是由α_2或β肾上腺素能受体介导的;（2）多巴胺能受体似乎不参与去卵巢猕猴LHRH脉冲性释放。
It has been postulated that catecholamines are integral to the control of LHRH release. In the present study, the roles of adrenergic and dopaminergic receptors in the control of pulsatile LHRH release are examined. The effects of prazosin (an αi-antagonist), rauwolscine (an α2-antagonist), propranolol (a β-antagonist), haloperidol (a dopamine antagonist), SCH23390 (a D1antagonist), and LY163502 (a D2agonist), on in vivo LHRH release in the stalk-median eminence were tested in ovariectomized female rhesus monkeys using push-pull perfusion. Prazosin caused a significant suppression of the LHRH release. This was primarily due to a significant suppression of LHRH pulse amplitude, but not pulse frequency, i.e. the interpulse interval was not affected by the administration of prazosin. In contrast to prazosin, none of the other adrenergic or dopaminergic drugs had significant effects on LHRH release. We conclude from these results that (1) the stimulatory effects of norepinephrine (NE) and/or epinephrine on pulsatile LHRH release are mediated by αi -adrenergic receptors but not α2or β-adrenergic receptors, and (2) dopaminergic receptors do not appear to be involved in pulsatile LHRH release in ovariectomized rhesus monkeys.