Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis
Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis
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DOI：
10.1016/s0026-0495(99)90265-2
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发表时间：
1999-10-01
影响因子：
9.8
通讯作者：
Tappy, L
中科院分区：
文献类型：
--
作者：
Schneiter, P;Gillet, M;Tappy, L
7名肝硬化患者和5名健康受试者在摄入葡萄糖餐后4小时内进行了研究，以确定肝脏非氧化性葡萄糖处理的改变是否参与糖耐量受损的发病机制。在连续输注c -13-半乳糖的过程中，通过尿对乙酰氨基酚葡萄糖醛酸的同位素富集来计算肝脏尿苷基二磷酸葡萄糖（UDPG）的周转率，并将其作为肝糖原合成的指标。肝硬化患者有餐后高血糖和葡萄糖清除率降低，但肝脏UDPG转化率没有改变（对照组为1.84 +/- 0.29 mg/kg无脂质量min v 1.76 +/- 0.15，无统计学意义）。结论：晚期肝硬化患者餐后肝糖原合成未发生改变，显示出重要的肝功能储备。版权所有(C) 1999由W.B. Saunders公司。
Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of C-13-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve. Copyright (C) 1999 by W.B. Saunders Company.