Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus
Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus
复制标题
毛果芸香碱诱发癫痫持续状态期间的异常连接
DOI：
10.1142/s0129065719500291
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发表时间：
2020-05-01
影响因子：
8
通讯作者：
Guo, Daqing
中科院分区：
文献类型：
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作者：
Cui, Yan;Liu, Jie;Guo, Daqing
癫痫持续状态（SE）是一种常见的、危及生命的神经系统疾病，可能导致永久性脑损伤。在啮齿动物模型中，SE是癫痫发作的急性期，可通过注射匹鲁卡品复制，然后诱导慢性颞叶癫痫（TLE）发作。然而，SE如何破坏大脑活动，特别是大脑区域之间的通信，目前尚不清楚。在这项研究中，我们的目的是确定特征异常的额叶皮层，海马和丘脑之间的网络连接在SE事件的匹鲁卡品模型与功能和有效的连接测量。我们发现，在SE发作期间，这些区域之间的相干连接性在几乎所有频带（除α带）中显著增加，并且具有增强连接的频带特定于SE发作的不同阶段。此外，与有效的分析，我们揭示了一个封闭的神经回路之间的双向有效的相互作用的额叶区域和海马和丘脑在发作和发作后阶段，这意味着异常增强这些大脑区域之间的通信在SE事件。此外，从海马到丘脑的有效连接被检测到在发作前阶段，在发作阶段在相反的方向移动在发作阶段的θ带和θ，α，β和低γ带在发作后阶段的δ带。海马和丘脑之间有效连接的这种特异性说明海马结构对于SE放电的起始是至关重要的，而丘脑对于SE放电的传播是重要的。总的来说，我们的研究结果表明，增强的相互作用，额叶皮层，海马和丘脑在SE事件，并建议模式的信息流在这些结构的启动和传播的SE放电。这些发现可能揭示了匹罗卡品诱发SE放电过程中异常网络通讯的潜在机制，并加深了我们对TLE发作的认识。
Status epilepticus (SE) is a common, life-threatening neurological disorder that may lead to permanent brain damage. In rodent models, SE is an acute phase of seizures that could be reproduced by injecting with pilocarpine and then induce chronic temporal lobe epilepsy (TLE) seizures. However, how SE disrupts brain activity, especially communications among brain regions, is still unclear. In this study, we aimed to identify the characteristic abnormalities of network connections among the frontal cortex, hippocampus and thalamus during the SE episodes in a pilocarpine model with functional and effective connectivity measurements. We showed that the coherence connectivity among these regions increased significantly during the SE episodes in almost all frequency bands (except the alpha band) and that the frequency band with enhanced connections was specific to different stages of SE episodes. Moreover, with the effective analysis, we revealed a closed neural circuit of bidirectional effective interactions between the frontal regions and the hippocampus and thalamus in both ictal and post-ictal stages, implying aberrant enhancement of communication across these brain regions during the SE episodes. Furthermore, an effective connection from the hippocampus to the thalamus was detected in the delta band during the pre-ictal stage, which shifted in an inverse direction during the ictal stage in the theta band and in the theta, alpha, beta and low-gamma bands during the post-ictal stage. This specificity of the effective connection between the hippocampus and thalamus illustrated that the hippocampal structure is critical for the initiation of SE discharges, while the thalamus is important for the propagation of SE discharges. Overall, our results demonstrated enhanced interaction among the frontal cortex, hippocampus and thalamus during the SE episodes and suggested the modes of information flow across these structures for the initiation and propagation of SE discharges. These findings may reveal an underlying mechanism of aberrant network communication during pilocarpine-induced SE discharges and deepen our knowledge of TLE seizures.