Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors
Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors
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DOI：
10.3390/microorganisms8010114
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发表时间：
2020-01-01
期刊：
影响因子：
4.5
通讯作者：
Charrel, Remi N.
中科院分区：
文献类型：
--
作者：
Ayhan, Nazli;Prudhomme, Jorian;Charrel, Remi N.
托斯卡纳病毒（TOSV）是地中海盆地的地方病，在那里它是由白蛉传播的。TOSV可感染人类并引起发热性疾病以及影响中枢和外周神经系统的神经侵入性感染。虽然TOSV是一种重要的人类病原体，但它仍然被忽视，因此存在许多知识空白。最近的血清流行病学研究和病例报告表明，TOSV的地理分布比十年前假设的要广泛得多。TOSV循环区域的明显扩展提出了能够在自然条件下传播病毒的白蛉物种的问题。白蛉属Phlebotomus（Ph.）perniciosus和Ph.perfiliewi在历史上被确定为主管物种。最近的研究结果表明，其他种类的白蛉可以胜任TOSV的维护和传播。在这里，我们组织昆虫学，流行病学和病毒学的现有知识，支持可能存在的额外的白蛉物种，如Ph. longicuspis，Ph. sergenti，Ph. lubbi，Ph. neglectus和Sergentomyia minuta在TOSV维护。我们还强调了一些知识差距，以解决在未来的研究。
Toscana virus (TOSV) is endemic in the Mediterranean basin, where it is transmitted by sand flies. TOSV can infect humans and cause febrile illness as well as neuroinvasive infections affecting the central and peripheral nervous systems. Although TOSV is a significant human pathogen, it remains neglected and there are consequently many gaps of knowledge. Recent seroepidemiology studies and case reports showed that TOSV's geographic distribution is much wider than was assumed a decade ago. The apparent extension of the TOSV circulation area raises the question of the sandfly species that are able to transmit the virus in natural conditions. Phlebotomus (Ph.) perniciosus and Ph. perfiliewi were historically identified as competent species. Recent results suggest that other species of sand flies could be competent for TOSV maintenance and transmission. Here we organize current knowledge in entomology, epidemiology, and virology supporting the possible existence of additional phlebotomine species such as Ph. longicuspis, Ph. sergenti, Ph. tobbi, Ph. neglectus, and Sergentomyia minuta in TOSV maintenance. We also highlight some of the knowledge gaps to be addressed in future studies.