Effects of decompressive craniectomy on brain tissue oxygen in patients with intracranial hypertension
Effects of decompressive craniectomy on brain tissue oxygen in patients with intracranial hypertension
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DOI：
10.1136/jnnp.74.4.513
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发表时间：
2003-04-01
影响因子：
11
通讯作者：
Meixensberger, J
中科院分区：
文献类型：
--
作者：
Jaeger, M;Soehle, M;Meixensberger, J
本报告检查了3名患者在严重蛛网膜下腔出血和动脉瘤弹簧圈栓塞术后因弥漫性脑肿胀而导致的难治性颅内高压的手术去骨瓣减压术期间脑组织氧分压（PtiO2）和颅内压（ICP）的术中过程。平均颅内压从59 mm Hg下降到10 mm Hg，以两步的方式，与骨瓣切除和硬脑膜开放有关。同时，PtiO2从0.8 kPa（6 mm Hg）迅速增加至3.07 kPa（23 mm Hg）。术后PtiO2和ICP保持在非临界范围。尽管对ICP和PtiO2有这些有益的影响，但患者的临床状态仍然很差，其中2例处于持续植物状态，1例死亡。
This report examined the intraoperative course of partial pressure of brain tissue-oxygen (PtiO2) and intracranial pressure (ICP) during surgical decompressive craniectomy for medically intractable intracranial hypertension due to diffuse brain swelling in three patients after, severe subarachnoid haemorrhage and aneurysm coiling. The mean ICP decreased from 59 mm Hg to 10 mm Hg in a, two step fashion, relating to bone flap removal and dural opening. Simultaneously, PtiO2 increased rapidly from 0.8 kPa (6 mm Hg) to 3.07 kPa (23 mm Hg). PtiO2 and ICP remained at non-critical ranges postoperatively. Despite these beneficial effects on ICP and PtiO2, the patients' clinical status remained poor with two in a persistent vegetative state and one dead.