A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.
A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.
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DOI：
10.1097/psy.0b013e31821195ed
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发表时间：
2011-05
影响因子：
3.3
通讯作者：
Taylor SE
中科院分区：
文献类型：
--
作者：
Way BM;Taylor SE
本研究探讨了血清素转运基因（SLC6A4）启动子的多态性（5-HTTLPR）是否调节心血管对社会威胁的反应。心理健康的年轻人在以下三种条件中的一种下进行演讲和心算：a)评价性听众条件，给予不赞成和消极的非语言社会信号（n=59）；B)提供支持性社会信号的评价性观众条件（n=60）；c)无观众条件（n=65）。在应激任务前、中、后分别测量心率（HR）、收缩压和舒张压（SBP， DBP），以评估心血管反应性和恢复情况。在负观众条件下，5-HTTLPR与收缩压、舒张压和HR反应性存在显著相关。短/短基因型的个体反应性最强。在无观众条件下，矮个子/矮个子个体的DBP和HR反应性也大于矮个子/矮个子基因型个体。5-HTLPR与HR反应性的这些关联受性别的影响，仅限于女性。在心血管恢复方面，相对于相同条件下的其他基因型以及没有观众条件下的矮/矮个体，消极观众条件下的矮/矮个体的DBP恢复受损。5-HTTLPR调节心血管在威胁性社会环境下对压力的反应，这表明血清素系统可能参与了压力、冲突充斥的社会环境影响心血管相关健康结果风险的过程。
This study examined whether a polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat. Psychologically healthy young adults delivered a speech and performed mental arithmetic in one of three conditions: a) an evaluative audience condition that gave disapproving and negative nonverbal social signals (n=59); b) an evaluative audience condition that provided supportive social signals (n=60); or c) a no audience condition (n=65). Heart rate (HR) and systolic and diastolic blood pressure (SBP, DBP) were measured before, during, and after the stress tasks to assess cardiovascular reactivity and recovery. In the negative audience condition, there was a significant association between the 5-HTTLPR and SBP, DBP, and HR reactivity. Individuals with the short/short genotype showed the greatest reactivity. The DBP and HR reactivity of short/short individuals in the negative audience condition was also greater than that of individuals with the short/short genotype in the no audience condition. These associations of the 5-HTLPR with HR reactivity were moderated by gender, being limited to females. With respect to cardiovascular recovery, short/short individuals in the negative audience condition exhibited impaired DBP recovery relative to other genotypes in the same condition as well as short/short individuals in the no audience condition. The 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes.