SACCADIC SYSTEM PLASTICITY IN HUMANS
SACCADIC SYSTEM PLASTICITY IN HUMANS
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DOI：
10.1002/ana.410040405
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发表时间：
1978-01-01
影响因子：
11.2
通讯作者：
DAROFF, RB
中科院分区：
文献类型：
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作者：
ABEL, LA;SCHMIDT, D;DAROFF, RB
受试者患有继发于部分第三神经麻痹的内直肌轻瘫，被迫使用受影响的眼睛六天，而好的眼睛则不断贴上补丁。每天仔细测量扫视眼球运动;增益增加，时间常数为0.85天。然后将贴片切换到麻痹眼，增益降低，时间常数为1.54天。这证明了中枢神经系统的可塑性的脉冲和神经活动的步骤负责在成年人的扫视的产生。除了增益的变化，postsaccadic漂移速度和扫视速度/振幅关系的变化，在修补报告。从这些数据的分析中可以得出的主要结论是，增益变化是由脉冲宽度变化而不是脉冲高度（发射频率）完成的，脉冲高度没有明显改变。
A subject with a medial rectus paresis secondary to a partial third nerve palsy was forced to use the affected eye for six days while the good eye was constantly patched. Saccadic eye movements were carefully measured each day; the gain increased, with a time constant of 0.85 day. The patch was then switched to the paretic eye and the gain decreased, with a time constant of 1.54 days. This demonstrated central nervous system plasticity of the pulse and step of neural activity responsible for the generation of saccades in the adult human. In addition to gain changes, postsaccadic drift velocity and saccadic velocity/amplitude relationship alterations during the patching are reported. A major conclusion that can be drawn from analysis of these data is that the gain changing is accomplished by pulse width changes rather than pulse height (firing frequency), which was not markedly altered.