Quality of life among younger women with breast cancer
Quality of life among younger women with breast cancer
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DOI：
10.1200/jco.2005.05.130
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发表时间：
2005-05-20
影响因子：
45.3
通讯作者：
Manuel, J
中科院分区：
文献类型：
--
作者：
Avis, NE;Crawford, S;Manuel, J
目的描述年轻女性乳腺癌诊断后4 ~ 42个月的生活质量（QOL），并确定与生活质量受损相关的因素。方法对202名年龄在50岁以下、乳腺癌诊断后4 ~ 42个月的I ~ III期乳腺癌患者进行邮寄调查。全球生命质量;通过癌症治疗-乳腺癌功能评估（FACT-B）测量与健康相关的生活质量；病史;症状;诊断后缺少工作/活动天数；关系、性和身体形象问题；应对策略;并且测量了准备的感觉。结果70%以上的女性出现全身疼痛和外观不佳。潮热（P = .0007）、性交疼痛（P = .02）和膀胱控制困难（P = .002）均随着年龄的增长而显著增加。总体生活质量显著低于年轻女性非患者样本（P < 0.0001）。总体而言，与生活质量相关的社会人口学和医学因素较少。在多变量分析中，诊断后立即错过工作/日常活动天数；诊断后出现关系、性或身体形象问题；应对策略几乎与所有生活质量领域相关。正在进行的治疗，阴道干燥，以及对乳腺癌的影响毫无准备都与某些领域有关。结论年轻的乳腺癌幸存者在诊断后数年内存在生活质量受损的风险。年轻女性，尤其是那些生活质量较低的高风险女性，可能需要针对她们的更年期症状和人际关系、性功能和身体形象问题的需求进行干预。让年轻女性为乳腺癌的影响做好准备也可能是有益的。(c) 2005年由美国临床肿瘤学会出版。
Purpose To describe quality of life (QOL) of younger women 4 to 42 months after breast cancer diagnosis and to identify factors associated with impaired QOL.Methods A total of 202 women diagnosed with stage I to III breast cancer at age 50 or younger from 4 to 42 months after breast cancer diagnosis previously completed a mailed survey. Global QOL; health-related QOL as measured by the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B); medical history; symptoms; days of work/activity missed after diagnosis; relationship, sexual, and body image problems; coping strategies; and feelings of preparedness were measured.Results General aches and pains and unhappiness with appearance were reported by more than 70 % of women. Hot flashes (P = .0007), pain with sexual intercourse (P = .02), and difficulty with bladder control (P = .002) all significantly increased with age. Global QOL was significantly lower than for a nonpatient sample of younger women (P < .0001). In general, few sociodemographic and medical factors were related to QOL. In multivariate analyses, days of work/usual activity missed immediately after diagnosis; relationship, sexual, or body image problems after diagnosis; and coping strategies were related to almost all QOL domains. Ongoing treatment, vaginal dryness, and feeling unprepared for the impact of breast cancer were related to some domains.Conclusion Younger breast cancer survivors are at risk for impaired QOL up to several years after diagnosis. Younger women, especially those at high risk for lower QOL, may need interventions that specifically target their needs related to menopausal symptoms and problems with relationships, sexual functioning, and body image. Preparing younger woman for the impact of breast cancer may also prove beneficial. (c) 2005 by American Society of Clinical Oncology.