The roles of CymA in support of the respiratory flexibility of Shewanella oneidensis MR-1
The roles of CymA in support of the respiratory flexibility of Shewanella oneidensis MR-1
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DOI：
10.1042/bst20120150
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发表时间：
2012-12-01
影响因子：
3.9
通讯作者：
Butt, Julea N.
中科院分区：
文献类型：
--
作者：
Marritt, Sophie J.;McMillan, Duncan G. G.;Butt, Julea N.
希瓦氏菌是从氧化还原条件在时间和空间上波动的海水和水生沉积物的氧化/缺氧区分离出来的。这些环境的定居是凭借灵活的呼吸链，其中许多呼吸链以还原细胞外基质的能力而闻名，包括氧化物和层状硅酸盐矿物中所含的Fe(III)和Mn(IV)。单氏希瓦氏杆菌MR-1作为一个模式生物来考虑这种灵活性的生物化学基础。在本论文中，我们总结了不同的系统，用于分支呼吸链，以便从对苯二酚氧化的电子可以传递到各种末端的电子受体，能够支持有氧和厌氧生长。这突出了几个悬而未决的问题，涉及希瓦纳氏菌呼吸电子传递的调节以及含四氢喹啉脱氢酶CymA在这一过程中的中心作用(S)。
Shewanella species are isolated from the oxic/anoxic regions of seawater and aquatic sediments where redox conditions fluctuate in time and space. Colonization of these environments is by virtue of flexible respiratory chains, many of which are notable for the ability to reduce extracellular substrates including the Fe(III) and Mn(IV) contained in oxide and phyllosilicate minerals. Shewanella oneidensis MR-1 serves as a model organism to consider the biochemical basis of this flexibility. In the present paper, we summarize the various systems that serve to branch the respiratory chain of S. oneidensis MR-1 in order that electrons from quinol oxidation can be delivered the various terminal electron acceptors able to support aerobic and anaerobic growth. This serves to highlight several unanswered questions relating to the regulation of respiratory electron transport in Shewanella and the central role(s) of the tetrahaem-containing quinol dehydrogenase CymA in that process.