Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering
Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering
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DOI：
10.1089/ten.teb.2009.0639
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发表时间：
2010-08-01
影响因子：
6.4
通讯作者：
Dehghani, Fariba
中科院分区：
文献类型：
--
作者：
Annabi, Nasim;Nichol, Jason W.;Dehghani, Fariba
组织工程在疾病组织的再生和修复方面具有巨大的潜力，使得组织工程支架的开发成为生物医学研究的一个热门话题。由于其生物相容性和天然细胞外基质的相似性，水凝胶已成为工程组织支架的主要候选者。然而，精确控制水凝胶性质，如孔隙率，仍然是一个挑战。用于在聚合物中产生体积孔隙率的传统技术已经证明在用于组织工程的水凝胶中是成功的;然而，通常条件与直接细胞包封不相容。新兴技术已经证明了控制水凝胶中的孔隙率和微结构特征的能力，从而产生具有与天然组织相似的结构和功能的工程组织。在这篇综述中，我们探讨了控制水凝胶内的孔隙率和微结构的各种技术，并展示了结合这些技术的成功应用。
Tissue engineering holds great promise for regeneration and repair of diseased tissues, making the development of tissue engineering scaffolds a topic of great interest in biomedical research. Because of their biocompatibility and similarities to native extracellular matrix, hydrogels have emerged as leading candidates for engineered tissue scaffolds. However, precise control of hydrogel properties, such as porosity, remains a challenge. Traditional techniques for creating bulk porosity in polymers have demonstrated success in hydrogels for tissue engineering; however, often the conditions are incompatible with direct cell encapsulation. Emerging technologies have demonstrated the ability to control porosity and the microarchitectural features in hydrogels, creating engineered tissues with structure and function similar to native tissues. In this review, we explore the various technologies for controlling the porosity and microarchitecture within hydrogels, and demonstrate successful applications of combining these techniques.