Changes in apparent diffusion coefficients in the normal uterus during different phases of the menstrual cycle
Changes in apparent diffusion coefficients in the normal uterus during different phases of the menstrual cycle
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DOI：
10.1259/bjr/11056533
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发表时间：
2010-06-01
影响因子：
2.6
通讯作者：
Togashi, K.
中科院分区：
文献类型：
--
作者：
Kido, A.;Kataoka, M.;Togashi, K.
本研究调查了育龄妇女子宫带状结构(肌层、子宫内膜和交界区)的表观扩散系数(ADC)及其在月经周期中的变化。对7名健康女性(年龄24-31岁)进行了围排卵期、黄体期和月经期的磁共振成像。扩散加权成像在子宫正中矢状面采用单次激发回波平面成像序列，采用3个b值(b=0、500、1000 S mm(-2))。在ADC图上，将两个感兴趣区(ROI)放置在相应的带状结构上，测量三种子宫带状结构的ADC值。子宫肌层ADC值(个体内ADC值变化)为0.41x10(-3)mm(2)，S(-1)(0.08~0.91)，子宫内膜(0.55×10(-3)mm(-1))，S(-1)(0.35~0.84)，交界区(0.40×10(-3)mm(2)S(-1)(0.18~0.59))。子宫肌层和子宫内膜的ADC值在月经期较低，尽管个体的ADC值有一些重叠。特定区域或相位的ADC值的个体间变异范围为0.48×10(-3)mm(2)S(-1)到0.85x10(-3)mm(2)S(-1)。两个感兴趣区之间的测量误差为0~0.48×10~(-3)mm(2)S(~(-1))。这些变异的大小与报道的恶性和非恶性组织之间的差异相当。这些来自少数受试者的初步结果表明，在解释子宫结构的ADC值时，应该考虑绝经前妇女的月经周期和个体差异。
This study investigated the apparent diffusion coefficients (ADCs) of the uterine zonal structures (myometrium, endometrium and junctional zone) among reproductive women, and their changes during the menstrual cycle. Magnetic resonance (MR) images of seven healthy females (aged 24-31 years) were obtained during the periovulatory, luteal and menstrual phases. Diffusion-weighted imaging (DWI) was performed with a single-shot echo-planar imaging (EPI) sequence in the midsagittal plane of the uterus using three b-values (b=0, 500 or 1000 s mm(-2)). The ADC values of the three uterine zonal structures were measured on an ADCmap by placing two regions of interest (ROI) on the corresponding zonal structures. The average changes of ADC values (intra-individual ADC value variation) over three menstrual phases were 0.41 x 10(-3) mm(2) s(-1) (range, 0.08-0.91) for myometrium, 0.55 x 10(-3) mm(2) s(-1) (0.35-0.84) for endometrium, and 0.40 x 10(-3) mm(2) s(-1) (0.18-0.59) for the junctional zone. The ADC values for myometrium and endometrium were lower in the menstrual phase, although there was some overlap of individual values. Interindividual variation in ADC value for a given zone or phase ranged from 0.48 x 10(-3) mm(2) s(-1) to 0.85 x 10(-3) mm(2) s(-1). Intermeasurement variation between the two ROIs ranged from 0 to 0.48 x 10(-3) mm(2) s(-1) per measurement. The magnitude of these variations was comparable to reported differences between malignant and non-malignant tissues. These preliminary results, from a small number of subjects, suggest that the menstrual cycle and individual variation in pre-menopausal women should be considered when interpreting the ADC values of uterine structures.