A Survival Model in Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma.
A Survival Model in Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma.
复制标题
局部晚期和转移性胰腺导管腺癌的生存模型
DOI：
10.7150/jca.23984
复制
发表时间：
2018
影响因子：
3.9
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Wang Y;Xiao X;Wang T;Li L;Zhu Y;Xu H;Chu Y;Jiao F;Cui J;Wang L
血清LDH、CA 19 -9、CRP和ALB在PDAC患者预后中的作用存在争议。与单因素相比，关于四个因素的组合在局部晚期和转移性PDAC患者中的预后价值的信息要少得多。因此，有必要建立一个肿瘤代谢、肿瘤生物标志物、全身炎症和营养状况相结合的生存模型，以消除单一生物标志物对预后的影响。本研究招募了2009年至2017年接受姑息化疗的94例晚期PDAC患者。评估治疗前血清LDH、CA 19 -9、CRP和ALB水平对OS的预测价值，并与4个因素联合应用的预测价值进行比较。多因素分析证实血清LDH、CA 19 -9、CRP和ALB水平是影响OS的独立预后因素。Kaplan-Meier分析结果显示，血清LDH、CA 19 -9、CRP、ALB水平及其联合与OS相关，提示治疗前血清LDH、CA 19 -9、CRP、ALB水平联合是晚期PDAC患者的预后因素。
The prognostic role of serum LDH, CA19-9, CRP and ALB in PDAC patients are controversial. In contrast to single factor, there is much less information about the prognostic value of the combination of the four factors in locally advanced and metastatic PDAC patients. It's essential to set up a survival model with the combination of tumor metabolism, tumor biomarker, systemic inflammation and nutritional status to eliminate the prognostic inaccuracy in single biomarker. 94 advanced PDAC patients who received palliative chemotherapy from 2009 to 2017 were recruited for this study. The predictive value of pretreatment serum LDH, CA19-9, CRP and ALB levels for OS were evaluated, and the same as combination of the four factors. It was confirmed that serum LDH, CA19-9, CRP and ALB levels were independent prognostic factors for OS by multivariate analyses. The results of Kaplan-Meier analyses revealed that serum LDH, CA19-9, CRP, ALB levels as well as the combination of the four factors were correlated with OS. It's concluded that the combination of the pretreatment serum LDH, CA19-9, CRP and ALB levels is a prognostic factor for advanced PDAC patients.
登录
查看更多内容
影响因子：
3
作者：
Lee, Jae Min;Lee, Hong Sik;Kim, Chang Duck
通讯作者：
Kim, Chang Duck
影响因子：
64.8
作者：
Biankin, Andrew V.;Waddell, Nicola;Kassahn, Karin S.;Gingras, Marie-Claude;Muthuswamy, Lakshmi B.;Johns, Amber L.;Miller, David K.;Wilson, Peter J.;Patch, Ann-Marie;Wu, Jianmin;Chang, David K.;Cowley, Mark J.;Gardiner, Brooke B.;Song, Sarah;Harliwong, Ivon;Idrisoglu, Senel;Nourse, Craig;Nourbakhsh, Ehsan;Manning, Suzanne;Wani, Shivangi;Gongora, Milena;Pajic, Marina;Scarlett, Christopher J.;Gill, Anthony J.;Pinho, Andreia V.;Rooman, Ilse;Anderson, Matthew;Holmes, Oliver;Leonard, Conrad;Taylor, Darrin;Wood, Scott;Xu, Qinying;Nones, Katia;Fink, J. Lynn;Christ, Angelika;Bruxner, Tim;Cloonan, Nicole;Kolle, Gabriel;Newell, Felicity;Pinese, Mark;Mead, R. Scott;Humphris, Jeremy L.;Kaplan, Warren;Jones, Marc D.;Colvin, Emily K.;Nagrial, Adnan M.;Humphrey, Emily S.;Chou, Angela;Chin, Venessa T.;Chantrill, Lorraine A.;Mawson, Amanda;Samra, Jaswinder S.;Kench, James G.;Lovell, Jessica A.;Daly, Roger J.;Merrett, Neil D.;Toon, Christopher;Epari, Krishna;Nguyen, Nam Q.;Barbour, Andrew;Zeps, Nikolajs;Kakkar, Nipun;Zhao, Fengmei;Wu, Yuan Qing;Wang, Min;Muzny, Donna M.;Fisher, William E.;Brunicardi, F. Charles;Hodges, Sally E.;Reid, Jeffrey G.;Drummond, Jennifer;Chang, Kyle;Han, Yi;Lewis, Lora R.;Dinh, Huyen;Buhay, Christian J.;Beck, Timothy;Timms, Lee;Sam, Michelle;Begley, Kimberly;Brown, Andrew;Pai, Deepa;Panchal, Ami;Buchner, Nicholas;De Borja, Richard;Denroche, Robert E.;Yung, Christina K.;Serra, Stefano;Onetto, Nicole;Mukhopadhyay, Debabrata;Tsao, Ming-Sound;Shaw, Patricia A.;Petersen, Gloria M.;Gallinger, Steven;Hruban, Ralph H.;Maitra, Anirban;Iacobuzio-Donahue, Christine A.;Schulick, Richard D.;Wolfgang, Christopher L.;Morgan, Richard A.;Lawlor, Rita T.;Capelli, Paola;Corbo, Vincenzo;Scardoni, Maria;Tortora, Giampaolo;Tempero, Margaret A.;Mann, Karen M.;Jenkins, Nancy A.;Perez-Mancera, Pedro A.;Adams, David J.;Largaespada, David A.;Wessels, Lodewyk F. A.;Rust, Alistair G.;Stein, Lincoln D.;Tuveson, David A.;Copeland, Neal G.;Musgrove, Elizabeth A.;Scarpa, Aldo;Eshleman, James R.;Hudson, Thomas J.;Sutherland, Robert L.;Wheeler, David A.;Pearson, John V.;McPherson, John D.;Gibbs, Richard A.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.
影响因子：
45.3
作者：
Armstrong, Andrew J.;George, Daniel J.;Halabi, Susan
通讯作者：
Halabi, Susan
影响因子：
--
作者：
Li, Guo;Gao, Jin;Xia, Yun-Fei
通讯作者：
Xia, Yun-Fei
DOI：
10.1007/s00432-012-1371-3
发表时间：
2013-04-01
影响因子：
3.6
作者：
Haas, Michael;Heinemann, Volker;Boeck, Stefan
通讯作者：
Boeck, Stefan