ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE
ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE
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DOI：
10.1016/j.neuroscience.2010.04.024
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发表时间：
2010-07-14
期刊：
影响因子：
3.3
通讯作者：
Babiloni, C.
中科院分区：
文献类型：
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作者：
Brunetti, M.;Sepede, G.;Babiloni, C.
先前的功能性磁共振成像（fMRI）研究表明，严重创伤后应激障碍（PTSD）患者的杏仁核对情绪中性图片的反应在群体水平上被夸大[Hendler T， Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich a (2003) Neuroimage 19(3):587-600]。目前的功能磁共振成像研究验证了一个假设，即在症状轻微的患者和没有出现症状的受试者中，杏仁核反应不仅在对消极图像的反应中升高，而且在对中性图像的反应中也升高，这是疾病严重程度的一个功能。为此，研究人员对10名轻度创伤后应激障碍患者和10名健康对照者（都是银行抢劫案的受害者）进行了功能磁共振成像扫描，他们在执行一项视觉注意力任务时被要求观察情绪消极或中性的图片。与中性刺激相比，对照受试者对消极情绪刺激的杏仁核反应增强。相反，PTSD患者对中性和情绪图片的杏仁核反应均较高，两类刺激之间无统计学差异。在整个组中，我们发现在处理中性刺激时，PTSD症状的严重程度、任务表现和杏仁核激活之间存在相关性。本研究结果提示，轻度PTSD患者杏仁核反应和对中性刺激的情绪反应选择性随疾病严重程度的增加而升高。(c) 2010 ibro。Elsevier Ltd.出版。版权所有。
Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.