Paget disease of the breast: A pictorial essay
Paget disease of the breast: A pictorial essay
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DOI：
10.1148/radiographics.18.6.9821194
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发表时间：
1998-11-01
期刊：
影响因子：
5.5
通讯作者：
Cooper, LL
中科院分区：
文献类型：
--
作者：
Burke, ET;Braeuning, MP;Cooper, LL
乳腺Paget病约占乳腺癌的2%-3%。它的特点是腺癌细胞侵袭乳头表皮，导致乳头和乳晕上的湿疹。临床特征对该病有很高的提示作用；临床医生意识到这一点，应能更及时地诊断和更早地开始适当的治疗。虽然乳房X光检查并不总是阳性，但在所有病例中都应该得到Paget病的提示，以寻找潜在的肿瘤并指导进一步的治疗。在乳房X光检查中可以看到的发现包括皮肤增厚、乳头后缩、乳晕下或更多弥漫性恶性微钙化，以及一个或多个离散肿块。然而，乳房X光检查阴性不应改变治疗过程。相反，鉴别乳晕下乳房X光检查结果应提醒临床医生在乳头和乳晕区域寻找提示Paget病的体征。
Paget disease of the breast accounts for approximately 2%-3% of breast cancers. It is characterized by infiltration of the nipple epidermis by adenocarcinoma cells, which cause an eczematous eruption on the nipple and areola. The clinical features are highly suggestive of the disease; awareness of these an the part of the clinician should lead to more prompt diagnosis and earlier initiation of appropriate treatment. Mammograms, although not always positive, should be obtained in all cases suggestive of Paget disease to search for the underlying tumor and direct further treatment. Findings that may be seen at mammography include skin thickening, nipple retraction, subareolar or more diffuse malignant microcalcifications, and a discrete mass or masses. However, a negative mammogram should not alter the course of treatment. Conversely, identification of subareolar mammographic findings should alert the clinician to search for physical signs in the nipple and areolar region suggestive of Paget disease.