Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development.
Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development.
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DOI：
10.1161/circresaha.112.268144
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发表时间：
2012-07-06
影响因子：
20.1
通讯作者：
Libby P
中科院分区：
文献类型：
--
作者：
Quillard T;Libby P
尽管最近取得了进展，但心血管及相关代谢紊乱仍然是一个世界性的健康挑战。我们需要确定新的治疗靶点，开发用于临床的新药物，并以临床有效和成本效益高的方式部署它们。在过去的十年中，动脉粥样硬化病变的分子成像已经成为一个主要的实验工具，特别是通过提供一个直接的通道来了解动脉粥样硬化及其并发症的过程。本文综述了针对斑块形成、发展和破坏所涉及的关键过程的分子成像方法的现状，并强调了这些工具的改进和应用如何有助于新疗法的开发和评估。
Despite recent progress, cardiovascular and allied metabolic disorders remain a worldwide health challenge. We need to identify new targets for therapy, develop new agents for clinical use, and deploy them in a clinically-effective and cost-effective manner. Molecular imaging of atherosclerotic lesions has become a major experimental tool in the last decade, notably by providing a direct gateway to the processes involved in atherogenesis and its complications. This review summarizes the current status of molecular imaging approaches that target the key processes implicated in plaque formation, development, and disruption, and highlights how the refinement and application of such tools might aid the development and evaluation of novel therapeutics.