Distinct dendritic morphology across the blades of the rodent dentate gyrus.
Distinct dendritic morphology across the blades of the rodent dentate gyrus.
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DOI：
10.1002/syn.21900
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Marrone DF
中科院分区：
文献类型：
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作者：
Gallitano AL;Satvat E;Gil M;Marrone DF
齿状回（DG）是海马的一个区域，长期以来一直被认为是持久记忆形成和提取的关键介质。因此，有大量的研究调查这一领域。这些研究大多将DG视为一个均匀的结构，或者检查了沿着隔-颞轴神经元的差异。然而，最近的数据表明，存在的DG的上锥体和锥体下叶之间的功能区别，前者在空间任务中表现出更强大的反应。到目前为止，很少有解剖学研究在大鼠中解决了这种功能梯度，也没有研究在小鼠中这样做。为了解决这一问题，我们研究了树突状形态和棘密度在大鼠和小鼠海马颗粒细胞使用Golgi-Cox技术。我们发现，颗粒细胞的上锥体叶片的DG含有更多的树突状物质的区域接受空间信息的内侧perforant路径。这提供了一个潜在的解剖学基础的DG空间输入的不对称反应。
The dentate gyrus (DG) is a hippocampal region that has long been characterized as a critical mediator of enduring memory formation and retrieval. As such, there is a wealth of studies investigating this area. Most of these studies have either treated the DG as a homogeneous structure, or examined differences in neurons along the septal-temporal axis. Recent data, however, have indicated that a functional distinction exists between the suprapyramidal and infrapyramidal blades of the DG, with the former showing more robust responses during spatial tasks. To date, few anatomical studies have addressed this functional gradient in rats, and no study has done so in the mouse. To address this, we investigated dendritic morphology and spine density in hippocampal granule cells of rats and mice using the Golgi-Cox technique. We find that granule cells from the suprapyramidal blade of the DG contains greater dendritic material in the region receiving spatial information from the medial perforant path. This provides a potential anatomical substrate for the asymmetric response of the DG to spatial input.