A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparum
A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparum
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DOI：
10.4269/tropmed.1999.61-044
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发表时间：
1999-07-01
影响因子：
3.3
通讯作者：
Jeffery, GM
中科院分区：
文献类型：
--
作者：
Collins, WE;Jeffery, GM
对343例接受疟疾常规治疗的神经梅毒患者进行回顾性检查，以确定恶性疟原虫复发的中位数间隔。数据收集于1940年至1963年期间，位于南卡罗来纳哥伦比亚和乔治亚州米利奇维尔的国家卫生研究院实验室。寄生虫峰值几何平均天数分别为8、26.5、43.5、62、78.5和95.5 d。18.5、17、18.5、16.5和17天这4个高峰之间的间隔表明，在未感染的前100天内，不同优势寄生虫种群出现的时间是固定的。当对这些患者的数据进行平均峰值寄生虫计数检查时，该模式表明寄生虫计数持续下降，表明免疫力增强，这足以减少但不能消除随后的寄生虫种群。343例患者首发期和前5次复发期的几何平均峰值寄生虫数分别为40,350、6,975、5,090、3,820、3,455和2,375/亩。
A retrospective examination was made to determine median intervals between recrudescences of Plasmodium falciparum in 343 neurosyphilitic patients who were given malariatherapy, which was routine care at that time. Data were collected at the National Institutes of Health laboratories in Columbia, South Carolina and Milledgeville, Georgia during the period 1940 to 1963. The geometric mean days of peak parasite count for the patients were 8, 26.5, 43.5, 62, 78.5, and 95.5 days, respectively. The intervals between these peaks of 18.5, 17, 18.5, 16.5, and 17 days suggest a fixed time frame for the appearance of different dominant parasite populations during the first 100 days of patent infection. When the data from these same patients were examined for mean peak parasite counts, the patterns indicated a consistent decrease in parasite count suggestive of increasing immunity, which was sufficient to reduce bur not eliminate subsequent parasite populations. The geometric mean peak parasite counts for the 343 patients during the primary attack and the first 5 recrudescences were 40,350, 6,975, 5,090, 3,820, 3,455, and 2,375/mu l, respectively.