Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape
Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape
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DOI：
10.1016/j.ejca.2006.01.043
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发表时间：
2006-05-01
影响因子：
8.4
通讯作者：
Offidani, A
中科院分区：
文献类型：
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作者：
Simonetti, O;Goteri, G;Offidani, A
本研究的目的是利用免疫组织化学技术研究59例皮肤黑素细胞病变中T免疫反应细胞与CCR 10及其配体CCL 27表达之间的相互关系。恶性黑色素瘤T淋巴细胞密度由薄到中、厚依次降低（P < 0.0005）。CCR 10在良、恶性病变中均有表达，且与Breslow深度呈正相关（P = 0.0298），与T淋巴细胞密度呈负相关（P = 0.0231）。此外，与前哨淋巴结阴性的病例相比，前哨淋巴结阳性的病例有更高的CCR 10表达倾向（P = 0.0281）。当同时评估CCR 10和CCL 27表达时，CCR 10-/CCL 27-黑色素瘤倾向于具有更高的CD 3+和CD 8+淋巴细胞的平均密度。我们的研究结果表明，在人类黑色素瘤中，CCR 10和CCL 27可能会增加肿瘤细胞生长、侵入组织、扩散到淋巴结和逃避宿主免疫反应的能力。(c)2006爱思唯尔有限公司版权所有
Aim of this study was to investigate using immunohistochemistry techniques the interrelation between T immunoreactive cells and the expression of CCR10 and its ligand CCL27 in 59 cutaneous melanocytic lesions. in malignant melanomas, T lymphocyte density was significantly decreased from thin melanomas to intermediate and thick ones (P < 0.0005). CCR10 expression was found both in benign and malignant lesions and it was directly correlated with the Breslow depth (P = 0.0298) and inversely with T lymphocyte density (P = 0.0231). Moreover, cases with positive sentinel lymph node tended to have a higher CCR10 expression compared to cases with negative sentinel lymph node (P = 0.0281). When CCR10 and CCL27 expression were evaluated together, CCR10-/CCL27-melanomas tended to have a higher mean density of CD3+ and CD8+ lymphocytes. Our results suggest that in human melanomas CCR10 and CCL27 may act to increase the ability of neoplastic cells to grow, invade tissue, disseminate to lymph nodes and to escape the host immune response. (c) 2006 Elsevier Ltd. All rights reserved