Origins and clinical relevance of sarcopenia
Origins and clinical relevance of sarcopenia
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DOI：
10.1139/h01-006
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发表时间：
2001-02-01
期刊：
影响因子：
--
通讯作者：
Roubenoff, R
中科院分区：
文献类型：
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作者：
Roubenoff, R
肌肉减少症是随着正常衰老而发生的肌肉质量和力量的损失。因为肌肉减少症不是疾病的结果，它在所有的老年人中都可以看到。骨骼肌减少症显著增加老年人残疾和功能丧失的风险。肌少症的机制是复杂的，在此进行综述。目前尚不清楚哪些因素在决定肌肉减少症的严重程度或发展速度方面最重要。虽然渐进式阻力训练显然可以逆转和预防肌肉减少症，但对于衰老肌肉适应训练的机制知之甚少，或者这些适应是否反映了直接病理生理过程的逆转，或者是通过激活与最初导致退化的不同途径来补偿。随着发达国家人口持续老龄化，诊断、治疗和预防肌肉减少症对现代社会的健康和福祉将日益重要。
Sarcopenia is the loss of muscle mass and strength that occurs with normal aging. Because sarcopenia is not the result of a disease, it is seen in all aged adults. Sarcopenia markedly increases the risk of disability and loss of functional capacity in the elderly. The mechanisms underlying sarcopenia are complex and are reviewed here. It is not clear at this time which factors are most important in determining the severity or rate of development of sarcopenia. While progressive resistance training clearly can reverse and prevent sarcopenia, little is known about the mechanisms by which aged muscle adapts To training, or whether these adaptations reflect reversal of direct pathophysiological processes or compensation by activation of separate pathways from those lending to the deterioration in the first place. As populations in developed countries continue to age, diagnosing, treating, and preventing sarcopenia will be progressively more important to the health and well-being of modem societies.