Co-registration of high resolution MRI scans with partial brain coverage in non-human primates.
Co-registration of high resolution MRI scans with partial brain coverage in non-human primates.
复制标题
非人类灵长类动物的高分辨率 MRI 扫描与部分大脑覆盖的共同配准。
DOI：
10.1117/12.877024
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dawant,BenoitM
中科院分区：
文献类型：
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作者：
Lecoeur,Jérémy;Wang,Feng;Chen,LiMin;Li,Rui;Avison,MalcomJ;Dawant,BenoitM
中枢神经系统的动态结构和功能重塑发生在生物体的整个生命周期中，从分子到系统水平。MRI提供了几个优点来观察这种现象：它是非侵入性和非破坏性的，对比度可以调整以询问不同的组织特性，并且成像分辨率可以在同一会话中从皮层列到整个大脑网络。为了可靠地测量这些变化，随着时间的推移，高分辨率fMRI生成的功能图需要准确地注册。本文提出了一种新的方法，用于自动配准薄皮质MR体积与功能图对齐。这些习得集中在初级躯体感觉皮层，这是大脑前顶叶的一个区域，负责精细的触觉和本体感觉。目前，这些厚片从一次采集到另一次采集都是在大致相同的方向上采集的，然后用手配准。因为它们只覆盖皮层的一小部分，所以它们的直接自动配准是困难的。为了解决这个问题，我们提出了一种依赖于中间图像的方法，所述中间图像是用覆盖头部的较大部分的表面线圈获取的，其中可以将板配准到所述较大部分。由于表面线圈采集的图像遭受严重的强度衰减伪影，我们还提出了一种方法来注册这些。从三只松鼠猴获得的数据集的结果显示出30微米的配准精度。
Dynamic structural and functional remodeling of the Central Nervous System occurs throughout the lifespan of the organism from the molecular to the systems level. MRI offers several advantages to observe this phenomenon: it is non-invasive and non-destructive, the contrast can be tuned to interrogate different tissue properties and imaging resolution can range from cortical columns to whole brain networks in the same session. To measure these changes reliably, functional maps generated over time with high resolution fMRI need to be registered accurately. This article presents a new method for registering automatically thin cortical MR volumes that are aligned with the functional maps. These acquisitions focus on the primary somato-sensory cortex, a region in the anterior parietal part of the brain, responsible for fine touch and proprioception. Currently, these slabs are acquired in approximately the same orientation from acquisition to acquisition and then registered by hand. Because they only cover a small portion of the cortex, their direct automatic registration is difficult. To address this issue, we propose a method relying on an intermediate image, acquired with a surface coil that covers a larger portion of the head to which the slabs can be registered. Because images acquired with surface coils suffer from severe intensity attenuation artifact, we also propose a method to register these. The results from data sets obtained with three squirrel monkeys show a registration accuracy of thirty micrometers.