Methods: A small-molecule SMASh hit.

Methods: A small-molecule SMASh hit.
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方法:小分子 SMASh 击中。

DOI:
10.1038/nchembio.1886
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发表时间:
2015
影响因子:
14.8
通讯作者:
Zhou,Pengbo
Zhou,Pengbo
中科院分区:
生物学1区
文献类型:
--
作者:
Hannah,Jeffrey;Zhou,Pengbo

文献摘要

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有许多技术可用于在翻译后水平上控制基因表达。然而,一种名为SMASh(小分子辅助关闭)的新系统,它允许化学诱导目标蛋白的降解,呈现出一些明显的优势。
There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for chemically-induced degradation of target proteins, presents some distinct advantages.