A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy
A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy
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用于癌症治疗诊断的液体活检引导药物释放系统：整合快速循环肿瘤细胞检测和精准肿瘤治疗
DOI：
10.1039/d0lc00149j
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发表时间：
2020
期刊：
影响因子：
6.1
通讯作者：
Zhang Zhi-Ling
中科院分区：
文献类型：
--
作者：
Xu Chun-Miao;Tang Man;Feng Jiao;Xia Hou-Fu;Wu Ling-Ling;Pang Dai-Wen;Chen Gang;Zhang Zhi-Ling
结合精确诊断和同步治疗的治疗学作为一种有前途的治疗危及生命的癌症的策略受到了广泛的关注。液体活检通过分析肿瘤生物标志物提供了对癌症的实时评估，其中循环肿瘤细胞（循环肿瘤细胞）已被广泛用于监测疾病进展和治疗反应。本研究提出了一种基于磁控微流控平台的集癌症诊断和治疗功能于一体的液体活检引导药物释放系统（LBDR系统）。在微流控芯片上加载两种磁性纳米球，即识别纳米球和载药纳米球，以实现ctc的快速检测和药物控释。当ctc与识别MNs上的适配体结合时，与适配体杂交的互补链（cdna）被释放，然后与载药MNs结合，进一步触发抗癌药物的释放。根据检测到的ctc数量控制药物的释放量，根据诊断结果为个别患者提供有效的治疗。这种LBDR系统为癌症治疗提供了一种新的策略，并可能促进癌症个性化治疗的发展。
Theranostics combining precision diagnosis and concurrent therapy has attracted significant attention as a promising strategy against life-threatening cancer. Liquid biopsy provides a real-time assessment of cancer by the analysis of tumor biomarkers, among which circulating tumor cells (CTCs) have been widely used to monitor disease progression and therapeutic response. In this study, a liquid biopsy-guided drug release system (LBDR system) integrating cancer diagnostic and therapeutic functions on a magnetically controlled microfluidic platform is presented. Two kinds of magnetic nanospheres (MNs), recognition MNs and drug-loaded MNs, are loaded onto the microfluidic chip to integrate the rapid detection of CTCs and controlled drug release. When CTCs bind to aptamers on the recognition MNs, complementary strands (cDNAs) hybridized with the aptamers are released and then conjugated with drug-loaded MNs to further trigger the release of anti-cancer drugs. The amount of drug released is controlled according to the number of detected CTCs, which can provide effective treatment for individual patients according to the diagnostic results. This LBDR system provides a novel strategy for cancer therapy and may facilitate the development of personalized cancer therapy.