MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review).
MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review).
复制标题
MicroRNA 调节间充质干细胞成骨分化的信号通路（综述）
DOI：
10.3892/mmr.2016.5335
复制
发表时间：
2016-07
影响因子：
3.4
通讯作者：
Shuai C
中科院分区：
文献类型：
--
作者：
Peng S;Gao D;Gao C;Wei P;Niu M;Shuai C
成骨是一个复杂的多步骤过程，涉及间充质干细胞（MSCs）向成骨祖细胞、成骨前细胞、成骨细胞和骨细胞的分化，以及多种细胞类型之间的相互作用，以形成和重塑骨。成骨过程中的信号调节网络包括多种成分，包括生长因子、转录因子、微（mi） rna和效应器，其中许多成分通过正调控或负调控形成反馈回路，控制成骨分化的平衡。mirna已被发现在多个方面和多个信号通路中是成骨信号通路的重要调节因子。现就miRNA在骨组织工程领域作为骨植入替代物在MSCs成骨信号网络中的作用的研究进展作一综述。特别是，本文对哪些mirna促进或抑制成骨过程进行了分类，并总结了这些mirna参与的信号通路。对成骨过程中mirna特征的认识的提高为其在骨组织工程和骨病的转化研究中的应用提供了重要的一步。
Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells (MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro (mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.