Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse

Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse
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树突状细胞和 Th2 淋巴细胞在哮喘中的作用:小鼠嗜酸性粒细胞气道炎症的教训

DOI:
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发表时间:
2001
期刊:
Microscopy research and technique (Print)
影响因子:
--
通讯作者:
B. Lambrecht
B. Lambrecht
中科院分区:
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文献类型:
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作者:
Leonie S van Rijt;B. Lambrecht

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哮喘是一种慢性气道疾病,其特征为可变的气道狭窄、粘液分泌过多以及气道壁嗜酸性粒细胞浸润。现在认为哮喘是由产生 IL-4、IL-5、IL-9 和 IL-13 等细胞因子的 Th2 淋巴细胞控制的。已经开发出嗜酸性气道炎症和气道高反应性的动物模型来研究细胞或介质在哮喘发病机制中的作用。在这篇综述中,我们讨论了抗原呈递细胞、CD4+和CD8+T淋巴细胞、B淋巴细胞、NK细胞和肥大细胞在诱导和维持嗜酸性气道炎症、粘液分泌过多和气道高反应性中的作用。显微镜。资源。技术。 53:256–272, 2001。© 2001 Wiley-Liss, Inc.
Asthma is a chronic disorder of the airways characterized by variable airway narrowing, mucus hypersecretion, and infiltration of the airway wall with eosinophils. It is now believed that asthma is controlled by Th2 lymphocytes producing cytokines such as IL‐4, IL‐5, IL‐9, and IL‐13. Animal models of eosinophilic airway inflammation and airway hyperreactivity have been developed to study the contribution of cells or mediators in the pathogenesis of asthma. In this review, we discuss the role of antigen presenting cells, CD4+ and CD8+ T lymphocytes, B lymphocytes, NK cells, and mast cells in the induction and maintenance of eosinophilic airway inflammation, mucus hypersecretion, and airway hyperreactivity. Microsc. Res. Tech. 53:256–272, 2001. © 2001 Wiley‐Liss, Inc.
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发表时间: 1999-10-01
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