Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse
Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse
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树突状细胞和 Th2 淋巴细胞在哮喘中的作用:小鼠嗜酸性粒细胞气道炎症的教训
DOI:
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
B. Lambrecht
中科院分区:
文献类型:
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作者:
Leonie S van Rijt;B. Lambrecht
Asthma is a chronic disorder of the airways characterized by variable airway narrowing, mucus hypersecretion, and infiltration of the airway wall with eosinophils. It is now believed that asthma is controlled by Th2 lymphocytes producing cytokines such as IL‐4, IL‐5, IL‐9, and IL‐13. Animal models of eosinophilic airway inflammation and airway hyperreactivity have been developed to study the contribution of cells or mediators in the pathogenesis of asthma. In this review, we discuss the role of antigen presenting cells, CD4+ and CD8+ T lymphocytes, B lymphocytes, NK cells, and mast cells in the induction and maintenance of eosinophilic airway inflammation, mucus hypersecretion, and airway hyperreactivity. Microsc. Res. Tech. 53:256–272, 2001. © 2001 Wiley‐Liss, Inc.
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DOI:
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