Dynamic regulation of the dopamine transporter
Dynamic regulation of the dopamine transporter
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DOI：
10.1016/j.ejphar.2003.08.066
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发表时间：
2003-10-31
影响因子：
5
通讯作者：
Amara, SG
中科院分区：
文献类型：
--
作者：
Mortensen, OV;Amara, SG
在哺乳动物中枢神经系统中，多巴胺转运体（DAT）是清除细胞外空间多巴胺的主要机制。多巴胺能神经元上的多巴胺和其他神经递质（自受体和异受体）的突触前受体通过对细胞内信号系统的作用来调节多巴胺转运体的活性。多巴胺转运的急性突触前调节机制包括磷酸化对酶促速率的直接影响，通过改变驱动转运的电和化学梯度的间接影响和/或通过转运载体进出细胞表面来调节转运体数量。本文综述了多巴胺转运体活动动态调节机制的最新证据，这些机制在多巴胺信号的持续时间和振幅的形成中起着重要作用。(C) 2003 Elsevier B.V.版权所有
In the mammalian central nervous system the dopamine transporter (DAT) is the primary mechanism for clearance of dopamine from the extracellular space. Presynaptic receptors for dopamine and other neurotransmitters (auto-receptors and hetero-receptors) present on dopaminergic neurons are poised to regulate the activity of the dopamine transporter acutely through their actions on intracellular signaling systems. The mechanisms proposed for acute presynaptic regulation of dopamine transport include direct effects of phosphorylation on enzymatic rate, indirect effects through the alteration of the electrical and chemical gradients that drive transport and/or the modulation of transporter number through the trafficking of carriers to and from the cell surface. This review focuses on recent evidence for several distinct mechanisms which dynamically regulate dopamine transporter activity and thus have an important role in shaping the duration and amplitude of dopamine signals in the brain. (C) 2003 Elsevier B.V. All rights reserved.