Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.
Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.
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与全身麻醉作用的统一理论相矛盾：1901 年至 2001 年三种化合物的历史。
DOI：
10.1016/s1522-8649(03)50031-2
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Krasowski,MatthewD
中科院分区：
文献类型：
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作者：
Krasowski,MatthewD
150多年前，乙醚、氯仿和一氧化二氮被引入临床实践，彻底改变了医学和外科手术。然而，尽管有很长一段时间的临床应用，它一直难以阐明全身麻醉的分子基础。即使在今天，这个问题仍然是一个积极的调查和辩论的来源。虽然研究人员在世纪后半叶提出了各种理论的麻醉剂的行动，第一个“现代”理论的全身麻醉作用来自独立的工作迈耶和奥弗顿。迈耶和奥弗顿的观察得到了广泛的实验研究的支持，即某些化合物（旧术语中的“麻醉剂”）的麻醉效力与在脂质溶剂（如橄榄油）中的分配系数成正比。虽然这些结果没有证明任何特定的分子靶点，但这些结果通常被解释为指示脂质膜为麻醉剂作用部位（Meyer-Overton“类脂质”假说），Meyer描述如下：
The introduction of diethyl ether, chloroform, and nitrous oxide into clinical practice over 150 years ago revolutionized medicine and surgery. However, despite a long period of clinical use, it has been difficult to elucidate the molecular basis for general anesthesia. Even today this question continues to be a source of active inquiry and debate.Although investigators in the last half of the nineteenth century proposed various theories for the actions of anesthetics, the first ‘modern’theory for general anesthetic action came from the independent works of Meyer and Overton. The observation by Meyer and Overton, supported by extensive experimental investigation, was that the anesthetic potency of certain compounds (‘narcotics’ in the older terminology) varied in direct proportion to the partition coefficient in a lipid solvent such as olive oil. While these results did not prove any particular molecular target, the results were often interpreted to indicate the lipid membrane as the site of anesthetic action (the Meyer-Overton ‘lipoid’hypothesis), described as follows by Meyer: