Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)
Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)
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DOI：
10.1038/ajg.2012.453
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发表时间：
2013-04-01
影响因子：
9.8
通讯作者：
Hart, Andrew R.
中科院分区：
文献类型：
--
作者：
Chan, Simon S. M.;Luben, Robert;Hart, Andrew R.
目的：肥胖与促炎状态相关，促炎状态可能参与炎症性肠病（IBD）的病因学，其存在合理的生物学机制。我们的目的是进行第一个前瞻性队列研究，调查肥胖和事件IBD.METHODS的发展之间是否存在关联：共有300,724名参与者被招募到欧洲癌症和营养研究的前瞻性调查。在招募时，记录身高和体重加上身体活动和总能量摄入量的人体测量值，这些测量值来自经验证的问卷。监测该队列，以确定发生克罗恩病（CD）或溃疡性结肠炎（UC）的参与者。每个病例与四个对照组相匹配，条件Logistic回归用于计算吸烟，能量摄入和体力活动调整后的体重指数（BMI）的比值比（OR）：结果：在队列中，177名参与者发生UC事件和75名参与者发生CD事件。与UC（P趋势= 0.36）或CD（P趋势= 0.83）的正常BMI相比，四种较高的BMI类别之间没有关联。当BMI作为连续变量或二元变量进行分析时（BMI 18.5 = 25 kg/m（2）），缺乏相关性是一致的。身体活动和总能量摄入，影响BMI的因素，并没有显示出任何关联与UC（身体活动，P趋势= 0.79;总能量摄入，P趋势= 0.18）或CD（身体活动，P趋势= 0.42;总能量，P趋势= 0.11）。结论：肥胖作为衡量BMI是不相关的事件UC或CD的发展。需要肥胖的替代措施来进一步研究肥胖在IBD发病中的作用。
OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD.METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropometric measurements of height and weight plus physical activity and total energy intake from validated questionnaires were recorded. The cohort was monitored identifying participants who developed either Crohn's disease (CD) or ulcerative colitis (UC). Each case was matched with four controls and conditional logistic regression used to calculate odds ratios (ORs) for body mass index (BMI) adjusted for smoking, energy intake, and physical activity.RESULTS: In the cohort, 177 participants developed incident UC and 75 participants developed incident CD. There were no associations with the four higher categories of BMI compared with a normal BMI for UC (P-trend = 0.36) or CD (P-trend = 0.83). The lack of associations was consistent when BMI was analyzed as a continuous or binary variable (BMI 18.5 = 25 kg/m(2)). Physical activity and total energy intake, factors that influence BMI, did not show any association with UC (physical activity, P-trend = 0.79; total energy intake, P-trend = 0.18) or CD (physical activity, P-trend = 0.42; total energy, P-trend = 0.11).CONCLUSIONS: Obesity as measured by BMI is not associated with the development of incident UC or CD. Alternative measures of obesity are required to further investigate the role of obesity in the development of incident IBD.